PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews and discusses the effects of the transcription factor PU.1 on immune cell differentiation.

PU.1 is an E26 transformation-specific family transcription factor that is required for development of the immune system. PU.1 functions at both early and late stages of lymphoid and myeloid differentiation. At least 110 direct target genes of PU.1 have …

The haematopoietic-specific Ets family transcription factor PU.1 regulates many lymphoid- and myeloid-specific gene promoters and enhancers by interacting with multiple proteins during haematopoietic development.

PU.1, a transcription factor member of the E26 transformation-specific family, affects the function of a variety of immune cells in several physiological and pathological conditions.

Apr 1, 1999 · PU.1 is a member of the transcription factor family Ets that is expressed selectively on B cells, myeloid cells and macrophages. PU.1 regulates the expression of several genes, including those encoding immunoglobulins, receptors and enzymes.

Jun 3, 2010 · This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein–protein interactions with ...

Jan 21, 2020 · Establishing gene regulatory networks during differentiation or reprogramming requires master or pioneer transcription factors (TFs) such as PU.1, a prototype master TF of hematopoietic lineage...

Sep 1, 2005 · By using a conditional PU.1 knock-out model, we here show that HSCs express PU.1, and its constitutive expression is necessary for maintenance of the HSC pool in the bone marrow. Bone marrow HSCs disrupted with PU.1 in situ could not maintain hematopoiesis and were outcompeted by normal HSCs.

Nov 5, 2024 · In addition to its critical involvement in regulating the function of hematopoietic stem cells, PU.1 has been shown to regulate myeloid and lymphoid development in a graded manner with high levels of PU.1 favoring monocyte development and …

Oct 14, 2021 · The transcription factor PU.1 is a master hematopoietic regulator involved in hematopoietic stem cell maintenance and myeloid and B lymphoid lineages. 3,4 PU.1 does not function as an on/off switch; instead, graded expression levels determine its precise role in specific cell types, 5 and expression levels must be tightly controlled throughout ...