Mar 30, 2025 · PTGER3 (Prostaglandin E Receptor 3) is a Protein Coding gene. Diseases associated with PTGER3 include Mast Cell Neoplasm and Primary Hypertrophic Osteoarthropathy. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

Prostaglandin EP3 receptor (EP3, 53kDa), is a prostaglandin receptor for prostaglandin E 2 (PGE 2) encoded by the human gene PTGER3; [5] it is one of four identified EP receptors, the others being EP 1, EP 2, and EP 4, all of which bind with and mediate cellular responses to PGE 2 and also, but generally with lesser affinity and responsiveness, ...

PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis. E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.

Jan 4, 2025 · Title: PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis. E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.

PTGER3 plays a crucial role in regulating TNBC cell invasion, migration, and proliferation. Upregulation of PTGER3 weakens the epithelial–mesenchymal phenotype in TNBC and promotes ferroptosis both in vitro and in vivo by repressing glutathione peroxidase 4 (GPX4) expression.

Feb 11, 2025 · Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kgamma, AMPK and GRK2. E-prostanoid 3 receptor deficiency on myeloid cells protects against ischemic acute kidney injury via breaking the auto-amplification loop of necroinflammation.

Background: Inflammatory mediator prostaglandin E2-prostaglandin E2 receptor EP3 (PTGER3) signaling is critical for tumor-associated angiogenesis, tumor growth, and chemoresistance. However, the mechanism underlying these effects in ovarian cancer is not known.

PTGER3 plays a crucial role in regulating TNBC cell invasion, migration, and proliferation. Upregulation of PTGER3 weakens the epithelial-mesenchymal phenotype in TNBC and promotes ferroptosis both in vitro and in vivo by repressing glutathione peroxidase 4 (GPX4) expression.

PTGER3 is a prognostic marker in Kidney renal clear cell carcinoma, Kidney renal papillary cell carcinoma

Inflammatory mediator prostaglandin E2–prostaglandin E2 receptor EP3 (PTGER3) signaling is critical for tumor-associated angiogenesis, tumor growth, and chemoresistance. However, the mechanism underlying these effects in ovarian cancer is not known.