Negative reaction for Bcl-2 immunostaining confirmed the diagnosis of PTGC. PTGC is a pattern usually identified focally in a lymph node. The proportion of PTGC component is most …

Sep 24, 2002 · The most important method to discriminate floral follicular lymphoma from diffuse PTGC is molecular studies for gene rearrangement between bcl-2 (chromosome 8q21) and …

progressive transformation of germinal centers (PTGC) in 19 paraffin-embedded, H&E-, bcl-2–, CD20-, and CD3-stained lymph nodes. We enumerated the T cells (CD3+) and mantle B cells …

Shoot for 150-160 chars. Author: Girish Venkataraman, MD, MBBS; Timothy Carll, MD; Yanxia Li, MD Category: Lymph Node and Spleen: Reactive/infectious > Reactive nodal processes > …

Jan 9, 2003 · We studied mantle B-cell and T-cell ingression in hyperplastic follicles (HFs), follicular lysis (FL), and progressive transformation of germinal centers (PTGC) in 19 paraffin …

4 days ago · BCL-2 did not promote cell proliferation but inhibited cell death, as originally shown in growth factor dependent haematopoietic progenitor cell lines (e.g., FDC-P1) and in Eμ-Myc/Eμ …

Mar 13, 2019 · The case demonstrates a reactive-appearing lymph node with intact nodal architecture and with progressive transformation of germinal centers (PTGC). PTGC affects …

Mar 10, 2018 · Histologic sections showed variable fibrosis and large, irregular lymphoid follicles with prominent mantle zones penetrating the germinal centers, highlighted by Bcl-2 and/or IgD …

Sep 1, 2003 · We studied mantle B-cell and T-cell ingression in hyperplastic follicles (HFs), follicular lysis (FL), and progressive transformation of germinal centers (PTGC) in 19 paraffin …

Bcl-2 is the founding member of a large family of proteins that regulate cell survival and cell death. Since its discovery in B-cell lymphomas over 30 years ago, research on the biological …