Feb 20, 2017 · A recent structural and kinetic study of LRP6 peptide with a Ser/Pro-rich sequence showed not only that Axin-bound GSK-3 phosphorylates LRP5/6 but also that phospho …

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded in mammals by two genes that generate two related …

GSK-3 is a potential target in cancer due to its roles in various signaling pathways including the NF-κB protein which is often deregulated in cancer and can induce many pro-inflammatory …

Nov 27, 2021 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

Mar 18, 2014 · We present crystal structures of GSK-3 bound to its phosphorylated N-terminus and to two of the phosphorylated LRP6 motifs. A conserved loop unique to GSK-3 undergoes …

Oct 1, 2020 · Glycogen synthase kinase (GSK)-3α/β and the double-stranded RNA-dependent kinase PKR are two sentinel kinases that carry-out multiple similar yet distinct functions in both …

Glycogen synthase kinase (GSK)-3α/β and the double-stranded RNA-dependent kinase PKR are two sentinel kinases that carry-out multiple similar yet distinct functions in both the cytosol and …

May 12, 2022 · GSK-3 impairs microtubule (MT) stability and dynamics by phosphorylating microtubule binding proteins, reducing the autophagic flux through its ability to activate mTOR …

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues.

Aug 1, 2017 · GSK3 was one of the first identified substrates of the heavily studied oncogenic kinase AKT, phosphorylation by which inhibits GSK3 activity via the formation of an …