Sep 21, 2021 · Protein C deficiency means you don’t have enough of this substance (protein C) to protect you from excessive clotting. Your blood naturally needs to clot to stop internal bleeding. However, an excessive amount of clotting can lead to life-threatening problems including deep vein thrombosis and pulmonary embolism .

Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, [5]: 6822 [6] is a zymogen, that is, an inactive enzyme. The activated form plays an important role in regulating anticoagulation, inflammation, and cell death and maintaining the permeability of blood vessel walls in humans and other animals.

Apr 23, 2023 · Protein C and protein S are glycoproteins, predominantly synthesized in the liver, that are important components of the natural anticoagulant system in the body. [1] [2] They are Vitamin K dependent and serve as essential components in maintaining physiologic hemostasis.

Protein C and protein S are proteins in your blood that work together to prevent your blood from clotting too much. Tests of protein C and S use a sample of your blood to measure how much of these proteins you have and how well they're working.

Nov 18, 2019 · Protein C deficiency is a rare disorder, characterized by a reduction in the activity of protein C, a plasma serine protease involved in the regulation of blood coagulation. The active form of protein C, activated protein C (APC), exerts potent anticoagulant activity.

Sep 24, 2018 · Protein C deficiency occurs when a person is unable to produce strong enough protein C or do not have enough of the protein in their body. This deficiency upsets the balance in the...

However, establishing a diagnosis of hereditary protein C deficiency can be difficult, as many clinical states can lead to acquired protein C deficiency. This topic review discusses the diagnosis and management of protein C deficiency (inherited and acquired).

Learn about Protein C and S levels, their role in blood clotting, deficiency causes, symptoms, and testing. Discover diagnosis, treatment, and prevention strategies.

Protein C Deficiency - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.

Protein C deficiency is caused by mutations in the gene. This gene provides instructions for making protein C, which is found in the bloodstream and is important for controlling blood clotting. Protein C blocks the activity of (inactivates) certain proteins that promote blood clotting.