However, the overall process of peptide bond scission is essentially the same for all protease classes. Soluble serine proteases (a); cysteine proteases (b); aspartyl proteases (c); and ...

3 days ago · Proteases articles from across Nature Portfolio Atom RSS Feed Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids …

Aug 24, 2010 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and …

Mar 16, 2021 · Using the blood cascade proteases as a case study, we obtain protease substrate profiles that can be used to map specificity, cleavage entropy and allosteric effects and to …

Jul 1, 2003 · The availability of the human and mouse genome sequences has allowed the identification and comparison of their respective degradomes — the complete repertoire of …

Jul 13, 2020 · This Review focuses on protease-based tools for sensing and controlling protein function in cell biology.

The status of human protease research and prospects for future protease-targeted drugs are reviewed here, with reference to some key examples where protease drugs have succeeded …

Nov 28, 2018 · The first protease inhibitors were peptidomimetic molecules designed to look like the peptide linkages in the precursor polypeptide and therefore compete with the substrate.

Oct 30, 2014 · Here, Dickinson et al.present a protease PACE system that identifies clinically relevant mutations conferring resistance to protease inhibitors in only a few days of continuous …

Feb 17, 2022 · To program intercellular communication for biomedicine, it is crucial to regulate the secretion and surface display of signaling proteins. Here the authors develop RELEASE, a …