PKC is one of the key targets of noncanonical Wnt signaling, particularly in the Wnt/Ca (2+) pathway. Recently, data have implicated components of noncanonical Wnt/Ca (2+) and Wnt/planar cell polarity signaling in directly promoting the invasiveness and malignant progression of diverse forms of human cancer.

May 18, 2019 · Inactivating mutations of the tumor suppressor Adenomatosis Polyposis Coli (APC), which are found in familial adenomatosis polyposis and in 80% of sporadic colorectal cancers (CRC), result in constitutive activation of the Wnt/β-catenin pathway and tumor development in the intestine.

Dec 16, 2013 · Protein kinase C (PKC), a prototypical class of serine/threonine kinases, exemplifies specific signaling molecules that link multiple cellular processes to cancer.

High PRKCG improved PAAD and SKCM patients’ survival and reduced KIRC, PCPG, and UVM patients’ survival. Furthermore, elevated PRKCH was associated with better survival in ACC, CESC, CHOL, HNSC, KIRC, LIHC, LUAD, and PRAD, but …

May 1, 2018 · Gene regulatory network (GRN) analysis demonstrated Mtf2 directly regulates Wnt signaling in erythroblasts, leading to activated canonical Wnt signaling in Mtf2-deficient erythroblasts, while...

Mar 10, 2023 · Fusion genes involving homologs of protein kinase C (PKC) have been identified in a variety of tumors. We report the clinical and histologic presentation of 51 cutaneous melanocytic neoplasms with a PKC fusion gene (involving PRKCA in 35 cases, PRKCB in 15 cases, and PRKCG in a single case).

Jun 30, 2024 · XHP treatment downregulated Wnt signaling pathway-related genes, including CCND2, PRKCG, and CCN4. Moreover, XHP effectively inhibited glucose uptake and lactate production, leading to reduced HIF-1α and glycolytic enzymes (GLUT1, HK2, PKM2), suggesting its potential in attenuating the Warburg effect.

There are three Wnt signaling pathways that have been described so far: classical β-catenin dependent pathway, non-classical Wnt/calcium pathway and non-classical planar cell polarity pathway (Zhao et al., 2019; Abplanalp et al., 2021).

Jun 21, 2023 · PRKCG encodes PKC γ, which is categorized under the classical protein kinase C family. No studies have specifically established the relationship between PRKCG nsSNPs with structural and functional variations in PKC γ in the context of hepatocellular carcinoma (HCC).

Jul 8, 2023 · VSG layer is replaced with a different layer proteins (the procyclic acidic recurring proteins [PARP] or procyclin [33, 39]). Both VSG and PARP layer protein are anchored towards the lipid bilayer with PRKCG a covalently attached …