Mar 30, 2025 · PPP1R3B (Protein Phosphatase 1 Regulatory Subunit 3B) is a Protein Coding gene. Diseases associated with PPP1R3B include Hyperinsulinemic Hypoglycemia, Familial, 3 and Myoclonic Epilepsy Of Lafora 1. Among its related pathways are Beta-Adrenergic Signaling and Activation of cAMP-Dependent PKA.

Jun 23, 2017 · The gene of known function closest to the mapped region, PPP1R3B (protein phosphatase 1 regulatory subunit 3B), encodes a protein (G L) that regulates glycogen metabolism in the liver. We therefore sought to test the hypothesis that hepatic PPP1R3B is associated with glycemic traits.

The protein phosphatase 1 regulatory subunit 3B (PPP1R3B) gene is a target of farnesoid X receptor (FXR), which is a major regulator of bile acid metabolism. Both PPP1R3B and FXR have been suggested to take part in glycogen metabolism, which may ...

Sep 24, 2019 · PPP1R3B, another PP1 regulatory subunit that is highly expressed in the liver, acts downstream of PPP1R3G for relaying insulin-induced PPP1R3G phosphorylation to glycogen synthesis by binding to the dephosphorylated GS and promoting glycogen elongation.

Mar 4, 2023 · Here we investigate the consequences of both Ppp1r3b overexpression and deletion in mouse and cell models and find that dysregulated Ppp1r3b expression in either direction promotes metabolic dysfunction and liver injury.

Feb 8, 2025 · Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition. A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction.

Aug 17, 2024 · This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young.

Nov 25, 2020 · The protein phosphatase 1 regulatory subunit 3B (<i>PPP1R3B</i>) gene is a target of farnesoid X receptor (<i>FXR</i>), which is a major regulator of bile acid metabolism.

Oct 17, 2022 · PPP1R3B suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown.

Mar 15, 2007 · The protein phosphatase-1 (PP1) catalytic subunit (PPP1CA; 176875) is regulated by targeting subunits, such as PPP1R3B. PPP1R3B suppresses the rate at which PP1 dephosphorylates (i.e., inactivates) glycogen phosphorylase (see PYGL, 613741) and enhances the rate at which it activates glycogen synthase (see GYS2, 138571) (Doherty et al., 1995).