Polyhexamethylene biguanide (PHMB) is a broad-spectrum antiseptic which avoids many efficacy and toxicity problems associated with antimicrobials, in particular, it has a low risk of loss of susceptibility due to acquired antimicrobial resistance.

Polyhexamethylene biguanide (PHMB, polyhexanide) is known as a powerful biocide, active against a wide variety of bacteria, fungi, algae and viruses.1-4 Favorably, PHMB has low toxicity for humans and due to this it is used as biocide in swimming pools, as sanitizer in hospitals, as preservative in cosmetics and contact lens care solutions etc. ...

Antimicrobial dressings (AMDs) are a type of external help to infected chronic wounds. In this study, highly porous membranes made of only chitosan and containing the antiseptic polyhexanide (poly (hexamethylene biguanide); PHMB) were prepared by cryogelation, aiming to be used in AMDs.

A rapid and simple method for the determination of polyhexamethylene biguanide (polyhexanide, PHMB) in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection (HPLC–DAD) was developed.

Polyhexamethylene biguanide (PHMB), a broad spectrum disinfectant against many pathogens, was used as a stabilizing ligand for the synthesis of fairly uniform silver nanoparticles.

Jun 1, 2022 · In this work, the solvent effects of PHMB were investigated by FTIR, absorbance spectra, DFT, RDG, NBO, and VirtualToxLab analysis. It was understood that the chemical stability of PHMB was highest in the PHMB-H2O complexes.

Oct 19, 2023 · In order to address this issue, we developed an antiseptic Chitosan-Poly (hexamethylene) Biguanide (CS-PHMB) hydrogel. The prepared hydrogel was characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM).

May 22, 2019 · Attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) was used to assess PHMB levels on the surface of untreated PHMB:PU electrospun membranes and on membranes that had been immersed in PBS for 1 h, 4 h and then every 24 h up to 120 h to mimic use in vivo.

Polyhexamethylene biguanide hydrochloride (PHMB.HCL) has been utilized as a new antimicrobial providing reliable preservation in multipurpose solution (MPS) for hydrophilic contact lenses1,2. It is a polymeric compound with low skin irritancy, low eye toxicity, fast speed of kill, stable and effective over a wide pH range.

Dec 1, 2013 · A rapid and simple method for the determination of polyhexamethylene biguanide (polyhexanide, PHMB) in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection (HPLC–DAD) was …