Mar 30, 2025 · POLD3 (DNA Polymerase Delta 3, Accessory Subunit) is a Protein Coding gene. Diseases associated with POLD3 include Immunodeficiency 122 and Otitis Media . Among its …

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. [5] [6] It is a component of the DNA polymerase delta complex.

Dec 15, 2016 · Our findings demonstrate a key role of POLD1 and POLD3 in genome stability and S-phase progression revealing RNA-DNA hybrids-dependent effects for POLD3 that might be …

Jan 11, 2025 · POLD3, plays a crucial role in the efficient recycling of PCNA during dissociation-association cycles of pol delta during elongation phase of DNA replication. show that there is a …

DNA synthesis by Polδ and Polζ is mutagenic, but is needed for the survival of cells in the presence of DNA strand breaks. The POLD3 subunit of Polδ and Polζ is at the heart of DNA …

Apr 20, 2018 · By attempting to generate Pold3 deficient mice using CRISPR/Cas9 or transcription activator-like effector nucleases, we show that complete loss of Pold3 (Pold3-/-) …

Nov 19, 2024 · We highlight unexplored structural aspects of POLD3 and new biochemical data that will help to understand the pivotal role of POLD3 in DNA repair and mutagenesis in …

Mar 5, 2024 · POLD3 deficiency is associated with severe combined immunodeficiency, neurodevelopmental delay, and hearing impairment. Mehawej C, Chouery E, Azar-Atallah S, …

Jun 1, 2023 · Here we report a homozygous POLD3 variant (NM_006591.3; p.Ile10Thr) in a Lebanese patient, the product of a consanguineous family, presenting with a syndromic severe …

Dec 12, 2023 · The DNA polymerase δ complex (PolD), comprising catalytic subunit POLD1 and accessory subunits POLD2, POLD3, and POLD4, is essential for DNA synthesis and is central …