A podocyte has a complex structure. Its cell body has extending major or primary processes that form secondary processes as podocyte foot processes or pedicels. [6] The primary processes are held by microtubules and intermediate filaments. The foot processes have an actin-based cytoskeleton. [6]

Jan 28, 2016 · The genetic or acquired impairment of podocytes may lead to foot process effacement (podocyte fusion or retraction), a morphological hallmark of proteinuric renal diseases. Here, we briefly discuss aspects of a contemporary view of podocytes in glomerular filtration, the patterns of structural changes in podocytes associated with common ...

As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a unique geographical position: It is exposed to chemical signals from the urinary space (Bowman’s capsule), it receives and transmits chemical and ...

Podocyte function depends on a highly ordered cellular arrangement of filtration compartments and the correct signaling within this microenvironment.

This Research Topic represents a snapshot of the current concerns of the nephrological community regarding this cell and its particular microenvironment. The contributions presented in this Research Topic point to several key aspects of …

In this review, we take a membrane biologist's view of the podocyte, examining the many membrane receptors, channels, and other signaling molecules that have been implicated in podocyte biology.

Aug 30, 2016 · This Review discusses the role of podocyte actin dynamics in health and disease as well as the potential for personalized medicine approaches that target podocyte proteins.

A podocyte is a modified epithelial cell of the visceral layer of the glomerular capsule in the renal glomerulus; it has a small perikaryon and several primary and secondary foot-like radiating processes (pedicels) that interdigitate with those of other podocytes and embrace the walls of glomerular capillaries (Dorland, 2011).

The podocyte is partly responsible for the synthesis and turnover of the GBM, and podocyte-derived growth factors, particularly VEGF, are critical to the endothelial function.

Mar 5, 2025 · Podocyte injury is an established hallmark of kidney disease progression. Podocyte loss is a widely proven hypothesis to explain, in part, glomerular damage. Regardless of the underlying kidney disease, the pathophysiologic processes frequently involve the glomerulus. A growing body of evidence considered that podocytes detachment (podocytopathy) and their …