The Pirin Mountains (Bulgarian: Пирин [ˈpirin]) are a mountain range in southwestern Bulgaria, with the highest peak, Vihren, at an altitude of 2,914 m (9,560 ft). The range extends about 80 km (50 mi) from the north-west to the south-east and is about 40 km (25 mi) wide, spanning a territory of 2,585 km 2 (998 sq mi).

Here we summarize the biological functions of Pirin in relation to its role in cancer, suggesting that Pirin is a potential therapeutic target. Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins.

Pirin National Park (Bulgarian: Национален парк "Пирин"), originally named Vihren National Park, covering the larger part of the Pirin Mountains in southwestern Bulgaria, spanning an area of 403.56 square kilometers (155.82 sq mi).

Пѝрин, още Пирѝн и Перѝн, е планина в Югозападна България, част от Рило-Родопския планински масив, с най-висок връх Вихрен (2914,3 м). Най-старото познато име на планината е Орбелус – „белоснежна“, познато ни от траките, докато славяните са я наричали Перин или Перун.

Jan 28, 2022 · Using pharmacologic and genetic approaches to either downregulate or upregulate Nrf2, we show that pirin is regulated by Nrf2 in human and mouse cells and in the mouse colon in vivo.

May 28, 2013 · Pirin is a nuclear nonheme Fe protein of unknown function present in all human tissues. Here we describe that pirin may act as a redox sensor for the nuclear factor κB (NF-κB) transcription factor,...

The evolutionary conserved non-heme Fe-containing protein pirin has been implicated as an important factor in cell proliferation, migration, invasion, and tumour progression of melanoma, breast, lung, cervical, prostate, and oral cancers. Here we ...

Jan 15, 2021 · PIR is a nuclear redox sensor and regulator, and increasing it limits the oxidative damage of DNA and the subsequent cytoplasmic transport and extracellular release of HMGB1. In contrast, the depletion of PIR initiates HMGB1-dependent autophagy by binding to BECN1, and subsequently promotes ferroptosis by activating ACSL4.

Jan 9, 2004 · Pirin is a newly identified nuclear protein that interacts with the oncoprotein B-cell lymphoma 3-encoded (Bcl-3) and nuclear factor I (NFI). The crystal structure of human Pirin at 2.1-Å resolution shows it to be a member of the functionally diverse cupin superfamily.

Feb 25, 2025 · From the majestic peaks of Vihren to the serene waters of Popovo Lake, Pirin National Park is packed with stunning scenery. Stroll through the vibrant landscapes of Bansko, marvel at the natural beauty of Bezbog Lake, or explore the diverse trails of Koncheto Ridge.