Mar 4, 2012 · We show that Pinin physically interacts with RNPS1 and SAP18, forming an alternative ternary complex, PSAP. The expression of eukaryotic genes involves a series of steps ranging from...

Finally, we demonstrate that Pinin mediates glucose-stimulated nuclear export of NEAT1, through which it exerts isoform-specific and paraspeckle-independent functions. These findings establish a direct role for NEAT1 in regulating tumor metabolism, provide new insights into the Warburg effect, and identify potential targets for therapy.

Mar 3, 2016 · The phosphoprotein Pinin plays a key role in epithelial cell identity. We showed that clinical ovarian tumors and ovarian cancer cell lines express a high level of Pinin when compared with normal ovarian tissues and immortalized normal ovarian surface epithelial cell lines.

Unexpectedly, our structural analysis identified an Acinus-like motif in Pinin, another EJC-associated splicing factor. We show that Pinin physically interacts with RNPS1 and SAP18, forming an alternative ternary complex, PSAP.

Jun 7, 2002 · Pre-mRNA splicing occurs in a large macromolecular RNA–protein complex called the spliceosome. The major components of the spliceosome include snRNP and SR proteins. We have previously identified an SR-like protein, pinin (pnn), which is localized not only in nuclear speckles but also at desmosomes.

Jan 23, 2013 · Purpose: We investigated the impact of PININ (PNN) and epithelial splicing regulatory protein 1 (ESRP1) on alternative pre-mRNA splicing in the corneal epithelial context. Methods: Isoform-specific RT-PCR assays were performed …

Nov 11, 1996 · We have identified a protein named pinin that is associated with the mature desmosomes of the epithelia (Ouyang, P., and S.P. Sugrue. 1992. J. Cell Biol. 118:1477-1488). We suggest that the function of pinin is to pin intermediate filaments to the desmosome.

There are 2 potential isoforms mapped to this entry. Showing features for sequence conflict, compositional bias. Any medical or genetic information present in this entry is provided for …

Finally, we demonstrate that Pinin mediates glucose-stimulated nuclear export ofNEAT1, through which it exerts isoform-specific and paraspeckle-independentfunctions.

Feb 8, 2016 · The Pinin knockdown cell lines shared significant overlap of differentially expressed genes and RNA splicing aberrations with CtBP1 knockdown and in a lesser degree with CtBP2 knockdown cancer...