May 26, 2022 · Upon inducible deletion of CD8α, both naïve and memory CD8 + T cells spontaneously acquired activation phenotypes and subsequently died without exposure to specific antigens. PILRα was identified as a ligand for CD8α in both mice and humans, and disruption of this interaction was able to break CD8 + T cell quiescence.

Jul 12, 2022 · Paired immunoglobulin-like type 2 receptor alpha (PILRα) was recognized as the ligand for CD8α and blockade of PILRα-CD8α interaction would disrupt CD8 + T-cell …

Thus, the genetic ablation of PILRa in mice results in a partial phenotype as com-pared to the mAb against CD8a or PILRa. One possible interpretation for this discrepancy is that while interacting with CD8a to main-tain T cell quiescence, PILR may also engage

Aug 31, 2023 · Furthermore, Zheng L and colleagues lately found that PILRΑ could interact with CD8A and keep CD8 T cell in a quiescent state, thus maintaining the T cell pool size in the absence of antigen exposure 14. However, the involvement of PILRΑ in anticancer immunity remains poorly understood.

May 26, 2022 · We show here that CD8α is critical for the maintenance of CD8 + T cells in a physiologically quiescent state in peripheral lymphoid organs. Upon inducible deletion of CD8α, both naïve and memory CD8 + T cells spontaneously acquired activation phenotypes and subsequently died without exposure to specific antigens.

Jul 12, 2022 · Unique functions of splenic CD8alpha+ dendritic cells during infection with intracellular pathogens. Neuenhahn M, Busch DH. Immunol Lett. 2007 Dec 15;114 (2):66-72. doi: 10.1016/j.imlet.2007.09.007. Epub 2007 Oct 12. PMID: 17964665 Review. Running to Stand Still: Naive CD8 + T Cells Actively Maintain a Program of Quiescence.

Jul 12, 2022 · Paired immunoglobulin-like type 2 receptor alpha (PILRα) was recognized as the ligand for CD8α and blockade of PILRα-CD8α interaction would disrupt CD8 + T-cell quiescence. 1 Due to the...

Jul 22, 2022 · CD8α-PILRα interaction maintains the physiologically quiescent state of naive and memory CD8 + T cells in peripheral lymphoid organs. a In the steady-state, CD8 molecule expressed by naive and memory CD8 + T cells was occupied by PILRα (free or expressed by some cell types?) in the absence of antigen exposure to avoid unnecessary activation and ...

Paired immunoglobulin-like type 2 receptor alpha (PILR ) was recognized α as the ligand for CD8 and blockade of PILR -CD8 interaction α α α would disrupt CD8+ T-cell quiescence.1 Due to the...

Aug 31, 2023 · Furthermore, Zheng L and colleagues lately found that PILRΑ could interact with CD8A and keep CD8 T cell in a quiescent state, thus maintaining the T cell pool size in the absence of...