Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene. [5][6] Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids.

Mar 30, 2025 · PIK3CB (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PIK3CB include Nk-Cell Enteropathy and Seckel Syndrome. Among its related pathways are IL-9 Signaling Pathways and Translation Insulin regulation of translation.

Feb 8, 2025 · Pik3cb is a crucial direct target of YAP which regulates cardiomyocyte proliferation and survival. The PI3KBeta isoform was seen in dorsal horn neurons and dorsal root ganglia and has a role in inflammatory pain.

Apr 4, 2025 · Gene target information for PIK3CB - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Feb 8, 2025 · Enables 1-phosphatidylinositol-3-kinase activity and insulin receptor substrate binding activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of intracellular signal transduction; and response to …

Jan 2, 2015 · Pik3cb is a crucial direct target of YAP, through which the YAP activates phosphoinositol-3-kinase-AKT pathway and regulates cardiomyocyte proliferation and survival.

To investigate the molecular function of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB) underlying Alzheimer's disease (AD). RNA sequencing data were used to filtrate differentially expressed genes (DEGs) in AD/nondementia control …

The functional characterization of a PIK3CB catalytic domain mutant, p110β E1051K, first discovered by others in castrate-resistant prostate cancer (mCRPC), is outlined in this report; our data suggest that p110β E1051K is a gain-of-function mutation, driving PI3K signaling, tumorigenic cell growth and migration.

Nov 15, 2011 · Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli.

Aug 28, 2023 · PIK3CB is involved in the signal transduction of insulin (INS) and insulin-like pathways including the activation of the MAPK pathway [154]. A homologue of PIK3CB, age-1, has been related to ageing in roundworms [1518].