GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene. [5] [6] [7] This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface.

The PIGT gene provides instructions for making a protein called GPI transamidase component PIG-T (shortened to PIG-T protein). This protein is important for the attachment of certain proteins to the cell surface.

Aug 1, 2001 · PIG-S and PIG-T knockout cells (lanes 3 and 4), like GAA1 knockout cells (lane 2), synthesized and accumulated large amounts of mature forms of GPI, H7 and H8, and their precursors H5 and H6.

Aug 1, 2001 · PIG-S and PIG-T knockout cells were defective in transfer of GPI to proteins, particularly in formation of the carbonyl intermediates. We also demonstrate that PIG-S and PIG-T form a protein complex with GAA1 and GPI8, and that PIG-T maintains the complex by stabilizing the expression of GAA1 and GPI8.

Feb 24, 2022 · component PIG-T (shortened to PIG-T protein). This protein is important for the attachment of certain proteins to the cell surface. Specifically, the PIG-T protein attaches (binds) a molecule called a glycosylphosphatidylinositol (GPI) anchor to various proteins inside the cell. After the GPI anchor and protein are bound, the anchor

Dec 25, 2024 · Complete information for PIGT gene (Protein Coding), Phosphatidylinositol Glycan Anchor Biosynthesis Class T, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

The PIGT gene encodes PIG-T, a subunit of the 5-protein glycosylphosphatidylinositol (GPI) transamidase complex that catalyzes the attachment of a GPI anchor to a protein in the ER 16. PIG-T helps stabilize the GPI transamidase complex during GPI anchor attachment to proteins 16 .

Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. J. Biol. Chem. 278: 13959-13967, 2003.

Title: Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge.

Also known as: NDAP; PNH2; PIG-T; CGI-06; MCAHS3. See all available tests in GTR for this gene; Go to complete Gene record for PIGT; Go to Variation Viewer for PIGT variants; Summary. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI) …