In particular, the phospho‐Rab10–RILPL1 interaction negatively regulates primary ciliogenesis, which may contribute to PD pathologies . Rab phosphorylation by LRRK2 is also involved in …

Dec 18, 2023 · One of these substrates, Rab10, is phosphorylated at a conserved Thr73 residue (pRab10), and is one of the most abundant LRRK2 Rab GTPases expressed in various tissues.

VPS13C deficiency decreases lysosomal phospho-Rab10 and impairs phospho-Rab10-mediated lysosomal stress response. Having shown a phospho-dependent interaction between VPS13C …

Aug 20, 2019 · LRRK2 phosphorylates multiple RAB GTPases including RAB8A and RAB10. Phosphorylated RAB10 is recruited to centrosome-localized RILPL1, which may interfere with …

Aug 15, 2022 · The Parkinson's-disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases including Rab8 and Rab10, which enhances their binding to RILPL1 and RILPL2. …

Aug 31, 2017 · LRRK2 dependent phosphorylation of human Rab10 and human Rab12 at positions Thr73 and Ser106, respectively, was confirmed in HEK293 and, more importantly, …

Dec 18, 2023 · To establish the specificity of antibodies to the phosphorylated form of Rab10 (pRab10), Rab10 specific antisense oligonucleotides were intraventricularly injected into the …

Feb 15, 2024 · We identified Rab10 as a phospho-dependent interactor of VPS13C on lysosomes and observed a decreased phospho-Rab10-mediated lysosomal stress response upon loss of …

We identified Rab10 as a phospho-dependent interactor of VPS13C on lysosomes and observed a decreased phospho-Rab10-mediated lysosomal stress response upon loss of VPS13C.

One of these substrates, Rab10, is phosphorylated at a conserved Thr73 residue (pRab10), and is one of the most abundant LRRK2 Rab GTPases expressed in various tissues.