Phosphoglycerate dehydrogenase (PHGDH) is an enzyme that catalyzes the chemical reactions. The two substrates of this enzyme are 3-phospho-D-glycerate and NAD +, whereas its 3 products are 3-phosphohydroxypyruvate, NADH, and H +.

Mar 30, 2025 · Complete information for PHGDH gene (Protein Coding), Phosphoglycerate Dehydrogenase, including: function, proteins, disorders, pathways, orthologs, and expression.

Jul 1, 2024 · Researchers suggest that targeting PHGDH could be a promising strategy for cancer treatment, potentially improving outcomes for patients with tumors that overproduce PHGDH.

3-Phosphoglycerate dehydrogenase (PHGDH) is known to play important roles in cancer progression and migration 4, 5. PHGDH has the capacity to stabilize the oncogenic forkhead box protein M1, a factor implicated in tumor invasion, initiation, and proliferation processes 6.

PHGDH is the rate-limiting enzyme of de novo serine biosynthesis. PHGDH catalyses the conversion of the glycolytic intermediate 3-phosphoglycerate (3PG) to 3-phosphohydroxypyruvate (3PHP).

Feb 17, 2023 · Here, we report that phosphoglycerate dehydrogenase (PHGDH)-mediated endothelial cell (EC) metabolism fuels the formation of a hypoxic and immune-hostile vascular microenvironment, driving glioblastoma (GBM) resistance to chimeric antigen receptor (CAR)-T cell immunotherapy.

May 18, 2022 · Here we find that the loss of phosphoglycerate dehydrogenase (PHGDH) potentiates metastatic dissemination. Specifically, we find that heterogeneous or low PHGDH expression in primary tumours...

Feb 27, 2024 · In this study, we applied genetic approaches to ablate the Phgdh gene in macrophages and discovered that PHGDH was necessary for the immunosuppressive activation of the Th2 cytokine IL-4.

As a rate-limiting enzyme for the serine biosynthesis pathway (SSP) in the initial step, phosphoglycerate dehydrogenase (PHGDH) is overexpressed in many different tumors, and pharmacological or genetic inhibition of PHGDH promotes antitumor effects.

May 1, 2014 · The PHGDH gene provides instructions for making the parts (subunits) that make up the phosphoglycerate dehydrogenase enzyme. Learn about this gene and related health conditions.