Pepstatin is a potent inhibitor of aspartyl proteases. It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta (Iva-Val-Val-Sta-Ala-Sta). [1]

Pepstatin A is a pentapeptide isolated from Streptomyces testaceus. It is a potent inhibitor of aspartyl proteases. It has a role as a bacterial metabolite and an EC 3.4.23.* (aspartic endopeptidase) inhibitor.

Pepstatin is a low molecular weight, potent inhibitor specific for acid proteases with a Ki value of about 10(-10)M for pepsin. The chemical structure of pepstatin is essentially a hexapeptide which contains two residues of an unusual amino acid, 4-amino-3 …

Pepstatin A is a microbial hexapeptide produced by Actinomycetes spp. and a potent inhibitor of almost all types of aspartic proteases, including SAPs . This inhibitor modulates virulence of the SAP family and inhibits cell proliferation and adhesion to abiotic and biotic structures of Candida spp. showing promise as an antifungal therapeutic ...

Pepstatin is a low molecular weight, highly specific inhibitor of acid proteases, in particular aspartate proteases. It has been shown to inhibit virtually all acid proteases including pepsin, renin, cathepsin D, chymosin, protease B from Aspergillus niger, and proteases of microbial origin. The strict specificity of Pepstatin for acid ...

Pepstatin, discovered around 1970, was found to strongly inhibit pepsin and other members of the aspartic protease family. This compound is a relatively nonspecific inhibitor, as it seems to block most members of the aspartic protease class. Pepstatin contains an unusual amino acid, 3-hydroxy-4-amino-6-methylheptanoic acid.

Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases.

Jan 1, 2012 · Pepstatin is a strong inhibitor for all acid proteases. It does not inhibit other groups of proteases, such as the neutral and alkaline proteases (1). The unusual potency of pepstatin toward acid proteases is indicated by its Ki which was reported by Kunimoto et al....

Pepstatin A is an inhibitor of aspartic acid protease. It is highly selective without inhibiting thiol proteases, neutral proteases or serine proteases.

6 days ago · Pepstatin A treatment of osteoclast cells suppressed receptor activator of NF-κB ligand (RANKL)-induced differentiation to mononuclear osteoclast cells by blocking NFATc1 expression and inhibiting ERK signaling (4). Pepstatin A also inhibits human immunodeficiency virus (HIV) protease (5).