Pendrin is the protein which is mutated in Pendred syndrome, which is an autosomal recessive disorder characterized by sensorineural hearing loss, goiter and a partial organification problem detectable by a positive perchlorate test.

Oct 14, 2021 · Based on studies in pathophysiological states and the examination of genetically engineered mouse models, the evolving picture points to important roles for pendrin (SLC26A4) in kidney physiology and in disease states.

Pendrin is a Na(+)-independent Cl(-)/HCO3(-) exchanger that localizes to type B and non-A, non-B intercalated cells, which are expressed within the aldosterone-sensitive region of the nephron, i.e., the distal convoluted tubule, the connecting tubule, and the cortical collecting duct.

May 25, 2023 · Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder associated with sensorineural hearing...

Pendrin (SLC26A4, PDS) is an electroneutral anion exchanger transporting I(-), Cl(-), HCO(3)(-), OH(-), SCN(-) and formate. In the thyroid, pendrin is expressed at the apical membrane of the follicular epithelium and may be involved in mediating …

Pendrin is an anion transporter encoded by the PDS / Pds gene. In humans, mutations in PDS cause the genetic disorder Pendred syndrome, which is associated with deafness and goiter.

Pendrin, encoded by SLC26A4, is a transmembrane anion exchanger that belongs to the solute carrier 26 family and exchanges chloride, iodide, bicarbonate and formate. Mutations in SLC26A4 are the second most frequent cause of ARNSHL.

This review summarizes recent advances in the characterization of pendrin and the multiple roles it plays in the kidney, with emphasis on its essential roles in several diverse physiological processes, including chloride homeostasis, vascular volume and blood pressure regulation, calcium excretion and kidney stone formation.

Pendrin regulates vascular volume and blood pressure by mediating renal Cl − absorption. Moreover, pendrin-mediated Cl − absorption plays an important role in the increment in NaCl absorption and the subsequent rise in blood pressure that follow the administration of aldosterone or angiotensin II.

Pendrin is a 73 kDa membrane protein comprised of 780 amino acids (Scott and Karniski, 2000; Royaux et al., 2000). It is predicted to have 12 putative transmembrane domains with both the amino- and carboxy-termini located inside the cytosol (Fig. 2) …