Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti- tumorigenic, and neurotrophic functions.

Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles in many physiological and pathophysiological processes, ...

Objective: Pigment epithelium-derived factor (PEDF) is a multifunctional protein with neurotrophic and anti-angiogenic properties. More recently it became evident that PEDF is upregulated in patients with type 2 diabetes and also contributes to insulin resistance in mice.

Aug 1, 2003 · Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in many regions of the central nervous system against insults such as...

Pigment epithelium-derived factor (PEDF; encoded by SERPINF1 and also known as EPC1 and caspin), is a serpin that has multiple biological actions. The era of PEDF research began around 1990 with the discovery that PEDF is a differentiation factor for retinoblastoma cells 1, 2.

Pigment epithelium-derived factor (PEDF) is a natural protein of the retina with demonstrable neurotrophic properties, found in the interphotoreceptor matrix in intimate contact with photoreceptors. This review summarizes the effects of PEDF on ...

Sep 1, 2022 · Pigment epithelium-derived factor (PEDF), a potent inhibitor of angiogenesis, exerts antiangiogenic effects without affecting the structure and function of normal blood vessels. PEDF also has neurotrophic effects, which may be a potential direction for the future treatment of angiogenic diseases with lower side effects.

PEDF is a multifunctional protein that maintains diverse cell populations by regulating neurogenesis, stemness, and osteogenesis. In addition to regulating cell fate, PEDF also plays an important role in regulating angiogenesis, inflammation, oxidative stress, tumorigenesis, metastasis, and metabolism, which will not be discussed further here.

Sep 5, 2012 · Pigment epithelium-derived factor (PEDF) is a multifunctional serpin protein with demonstrable neurotrophic, antiangiogenic, antitumorigenic, antimetastatic, anti-inflammatory, antioxidative properties among others.

Already established as a potent anti-angiogenic molecule, PEDF has recently shown promise as a potential anti-tumour agent, causing both direct and indirect tumour suppression. Here, we explore the unique anti-tumour properties of PEDF and discuss its role as an effective anti-angiogenic, anti-proliferative and pro-differentiation factor.