Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.

The PDGFRB gene provides instructions for making a protein called platelet-derived growth factor receptor beta (PDGFRβ), which is part of a family of proteins called receptor tyrosine kinases. Learn about this gene and related health conditions.

Mar 30, 2025 · PDGFRB (Platelet Derived Growth Factor Receptor Beta) is a Protein Coding gene. Diseases associated with PDGFRB include Kosaki Overgrowth Syndrome and Premature Aging Syndrome, Penttinen Type. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Apr 7, 2025 · Gene target information for PDGFRB - platelet derived growth factor receptor beta (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating with the grade of myelofibrosis, knowledge on the precise role of PDGFRβ signaling in myelofibrosis is sparse.

We focused on examining regulation of Pdgfrb by TGFβ1, which encodes a tyrosine kinase receptor for PDGF-BB. We found that the ~150bp Pdgfrb promoter can respond to TGFβ stimulation and that this response relies on the two SP1 binding sites within the promoter.

Feb 15, 2025 · The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton.

Platelet-derived growth factor receptor β (PDGFRβ) belongs to the family of receptor tyrosine kinases and is widely known for regulating cellular functions like proliferation, angiogenesis, migration, and invasion [54]. TGF-β acts as one of the upstream modulators of PDGFRβ that facilitates EMT induction [55].

The PDGFRB gene encodes platelet-derived growth factor receptor-beta, a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family (see, e.g., PDFGB, 190040).

Feb 8, 2025 · Enables platelet-derived growth factor receptor activity and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and vasculature development.