Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. [2] .

Platelet-Derived Growth Factors (PDGFs) are a family of four cystine-knot-type growth factors (PDGF-A, -B, -C and -D) which control the growth of connective tissue cells such as fibroblasts and smooth muscle cells [1, 2].

Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors (PDGFRs) have been implicated in the pathogenesis of a number of tumor types and play an important role in angiogenesis.

The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases allows cells to communicate with the environment to regulate diverse cellular activities. Here, we highlight recent data investigating the structural makeup of individual PDGFRs upon activation, revealing the importance of the whole receptor in the ...

May 1, 2023 · The platelet derived growth factor receptor alpha (PDGFRα) has been regarded as a significant factor in the growth, angiogenesis, and spread of metastatic tumours. It served as a target for tyrosine kinase (TK) inhibitors that were developed for …

Biologically active (able to activate a PDGF receptor (PDGFR)) PDGF is a dimer of two PDGF protein chains. Extracellular, proteolytic processing is required for activation of some isoforms of PDGF (PDGF-C and PDGF-D), while this step occurs intracellularly for …

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration, primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed in a wide array of pathological conditions, such as cancer, fibrosis, neurological conditions and …

By directly stimulating tumour cells in an autocrine manner or by stimulating tumour stromal cells in a paracrine manner, the platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR) pathway is crucial in the growth and spread of several cancers.

Platelet-derived growth factor receptor (PDGFR) is another RTK signaling molecule with documented upregulation of expression in a subset of GBM. 27 Inhibitors of PDGFR include the drugs imatinib, dasatinib (Sprycel), tandutinib, and pazopanib (Votrient). Imatinib, an inhibitor of PDGFR as well as other selected RTKs (including KIT and ABL), is ...

Platelet-derived growth factor receptor (PDGFR) signaling plays a crucial role in specifying mesenchymal stem cell (MSC) commitment to mesenchymal lineages. Platelet-derived growth factor signaling critically regulates postinfarction repair.