May 28, 2020 · p21 Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 …

Apr 2, 2019 · Shape-based clustering revealed that the dynamics of the CDK inhibitor p21 diverges from the dynamics of its transcription factor p53 during S phase. Using mathematical …

CDK inhibition by p21 triggers cell-cycle arrest in the G1 and G2 phases of the cell cycle. In the absence of exogenous insults causing replication stress, only residual p21 levels are prevalent …

Jun 1, 2016 · P21 phosphorylation in Thr 145 disrupts the hydrogen bond between p21 and PCNA. The released PCNA activates DNA polymerase δ, promotes cell cycle progression …

Dec 15, 2008 · Interestingly, both the cyclin dependent kinase (CDK) and proliferating cell nuclear antigen (PCNA) binding domains of p21 are involved in different aspects of the modulation of …

PCNA seems to act as an important mediator of p21 function, which raises the mechanistic question of how p21 is able to regulate both the cell cycle and DNA replication. A likely …

In this study, we have investigated the kinetics of p21 induction by DNA damage and serum stimulation and the consequent effects on cell-cycle progression. Using both normal and repair …

Apr 4, 2010 · We propose a novel model in which CRL4 CDT2 -dependent protein degradation facilitates a sequential and dynamic exchange between PIP box-bearing proteins at stall forks …

Oct 1, 2008 · The p21 protein (also known as CDKN1A and p21 Cip1/Waf1), a member of the family of cyclin-dependent kinase (CDK) inhibitors (CKIs), has been shown to interact with …

Apr 2, 2019 · Shape-based clustering revealed that the dynamics of the CDK inhibitor p21 diverges from the dynamics of its transcription factor p53 during S phase. Using mathematical …