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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Functions of SAGA in development and disease - PMC
Gcn5 functions within a multi-subunit complex, called SAGA, that is recruited to specific genes through interactions with sequence-specific DNA-binding proteins to aid in gene activation.
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Nature
https://www.nature.com › articles
Dynamic modules of the coactivator SAGA in eukaryotic …
Jul 3, 2020 · SAGA (Spt-Ada-Gcn5 acetyltransferase) is a highly conserved transcriptional coactivator that consists of four functionally independent modules. Its two distinct enzymatic …
- Author: Youngseo Cheon, Harim Kim, Kyubin Park, Minhoo Kim, Daeyoup Lee
- Publish Year: 2020
Cell Press
https://www.cell.com › cell-reports › fulltext
The related coactivator complexes SAGA and ATAC …
Aug 24, 2021 · SAGA (Spt-Ada-Gcn5 acetyltransferase) and ATAC (Ada-two-A-containing) are two related coactivators, sharing the same histone …
Author: Veronique Fischer, Damien Plassard, Tao Ye, Bernardo Reina-San-Martin, Matthieu Stierle, Laszlo Tora...
Publish Year: 2021
Studies of Pcaf Saga
National Center for Biotechnology Information
SAGA and ATAC Histone Acetyl Transferase Complexes Regulate Distinct Sets of Genes and ATAC Defines a Class of p300-Independent Enhancers
Histone acetyltransferase (HAT) complexes are coactivators that are important for transcriptional activation by modifying chromatin. Metazoan SAGA and ATAC are distinct multisubunits complexes that share the same catalytic HAT subunit (GCN5 or PCAF). Here, we show that these human HAT complexes are ...
Author: Arnaud R. Kre…
Published: 2011/11/11
DOI: 10.1016/j.molcel.2…
ScienceDirect
Complex functions of Gcn5 and Pcaf in development and disease☆
A wealth of biochemical and cellular data, accumulated over several years by multiple groups, has provided a great degree of insight into the molecular mechanisms of actions of GCN5 and PCAF in gene activation. Studies of these lysine acetyltransferases (KATs) in vitro, in cultured cells, have revea...
Published: 2021/02/01
Cited By: 0
Keywords: Gcn5; Pcaf…
PubMed
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo
GCN5 is a histone acetyltransferase (HAT) originally identified in Saccharomyces cerevisiae and required for transcription of specific genes within chromatin as part of the SAGA (SPT-ADA-GCN5 acetylase) coactivator complex. Mammalian cells have two distinct GCN5 homologs (PCAF and GCN5L) that have b...
Author: E Martinez
Published: 2001/10
Keywords: National In…
PubMed
Functions of SAGA in development and disease
Precise regulation of gene expression programs during embryo development requires cooperation between transcriptional factors and histone-modifying enzymes, such as the Gcn5 histone acetyltransferase. Gcn5 functions within a multi-subunit complex, called SAGA, that is recruited to specific genes thr...
Author: Li Wang
Published: 2014/6
Keywords: ATAC com…
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Complex functions of Gcn5 and Pcaf in development …
The SAGA complex protein SUPT20 (also known as P38-Interacting protein (P38IP)) regulates monocyte and macrophage differentiation in part by regulating the stability of GCN5 in the SAGA complex . GCN5/PCAF regulates innate …
Journal of Biological Chemistry
https://www.jbc.org › article › fulltext
KAT tales: Functions of Gcn5 and PCAF lysine acetyltransferases in …
This review will focus on functions subsequently identified for Gcn5 and the closely related PCAF protein, in the context of two major complexes, SAGA and ATAC, and how the study of these …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
The SAGA chromatin-modifying complex: the sum of its parts is …
The Gcn5 family member proteins are PCAF (p300/CBP-associated factor, also known as KAT2B) and two isoforms of GCN5 (Gcn5-L and Gcn5-S). The PCAF protein shares extensive …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
SAGA and ATAC Histone Acetyl Transferase Complexes Regulate …
Nov 4, 2011 · The metazoan ATAC (Ada-Two-A-Containing) and SAGA (Spt-Ada-Gcn5-Acetyl-transferase) complexes are distinct multisubunit coactivators that share several subunits …
- Author: Arnaud R. Krebs, Krishanpal Karmodiya, Marianne Lindahl-Allen, Kevin Struhl, Làszlò Tora
- DOI: 10.1016/j.molcel.2011.08.037
- Publish Year: 2011
- Published: 2011/11/11
Science | AAAS
https://www.science.org › doi
The KAT module of the SAGA complex maintains the …
May 31, 2024 · We characterized the DNA recruitment sites of the SAGA complex in neuroblastoma and the consequences of loss of SAGA complex lysine acetyltransferase (KAT) activity on histone acetylation and gene expression.
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Complex functions of Gcn5 and Pcaf in development and disease
Feb 1, 2021 · Gcn5 and Pcaf play important roles in both the innate and adaptive immune systems. GCN5/PCAF KAT activity is linked with the survival of human cancer cell types, …
nature.com
https://www.nature.com › articles
The SAGA continues: expanding the cellular role of a ... - Nature
Aug 13, 2007 · The yeast Spt-Ada-Gcn5-Acetyl transferase (SAGA) transcriptional co-activator complex regulates numerous cellular processes through coordination of multiple histone post …
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