Mar 1, 2022 · Physiologically based pharmacokinetic (PBPK) modeling and physiologically based biopharmaceutics modeling (PBBM) are invaluable tools with wide applications during drug discovery and development stages.

As such, PBPK modeling has become a promising tool in predicting systemic 73 drug exposure (Kostewicz et al. 2014a) and has been used for dose selection, food effect

Feb 24, 2025 · In the complex world of R&D, acronyms like PBPK and PBBM often seem interchangeable—but they’re not. These two powerful modeling approaches play distinct roles in drug development, and understanding their differences can make a difference in your research or regulatory strategy.

Physiologically based pharmacokinetic (PBPK) models represent mechanistic models, which integrate a series of different mathematical equations describing the processes a drug undergoes in a human (or animal) organism.

Physiology based biopharmaceutics modeling (PBBM), the application of PBPK for biopharmaceutics applications, is an evolving tool that can be used throughout drug product development (model informed drug development), regulatory …

PBPK analyses use models and simulations that combine physiology, population, and drug substance and product characteristics to mechanistically describe the pharmacokinetic (PK) and/or...

Jul 23, 2023 · Over the past few years, PBPK and PBBM modelling have proven their significance in drug development. PBPK modelling is traditionally used to predict drug-drug interactions, exposures in special populations whereas PBBM modelling is a part of PBPK modelling that is used for a range of biopharmaceutic …

PBPK models have been used by drug developers to predict and evaluate the effect of various intrinsic and extrinsic patient factors, alone or in combination, on the exposure of investigational...

In this review, we proposed practical considerations for a "base" PBPK model construction and development, summarized current status, challenges including model validation and gaps in system models, and future perspectives in PBPK evaluation to assess a) drug metabolizing enzyme (s)- or drug transporter (s)- mediated drug-drug interactions b) do...

Seamlessly define inputs for your PBPK & PBBM models using the top-rated quantitative structure-activity relationship (QSAR) models from ADMET Predictor®. Strengthen the in vitro-in vivo extrapolation of dissolution & absorption inputs with DDDPlus™ and MembranePlus™.