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https://pmc.ncbi.nlm.nih.gov › articles
PAX7, a Key for Myogenesis Modulation in Muscular …
Pax7 and MyoD interact with each other during myogenesis, making them ideal markers for determining the cells’ quiescent, activation and myogenic status. The Pax7 and MyoD proportions of satellite cell subpopulations have well …
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PubMed
https://pubmed.ncbi.nlm.nih.gov
Pax7 and myogenic progression in skeletal muscle satellite cells
May 1, 2006 · Quiescent satellite cells express the transcription factor Pax7 and when activated, coexpress Pax7 with MyoD. Most then proliferate, downregulate Pax7 and differentiate. By …
- Author: Peter S. Zammit, Frederic Relaix, Yosuke Nagata, Ana Pérez Ruiz, Charlotte A. Collins, Terence A. Pa...
- Publish Year: 2006
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Marking the tempo for myogenesis: Pax7 and the regulation of …
Pax7 may act downstream the induction of MyoD expression regulating MyoD activity, preventing myogenin induction and thus, muscle differentiation. This dual role of Pax7 may allow for the …
Studies of Pax7 MyoD
PubMed
Pax7 and myogenic progression in skeletal muscle satellite cells
Skeletal muscle growth and regeneration are attributed to satellite cells - muscle stem cells resident beneath the basal lamina that surrounds each myofibre. Quiescent satellite cells express the transcription factor Pax7 and when activated, coexpress Pax7 with MyoD. Most then proliferate, downregul...
Author: Peter S Zammit
Published: 2006/05/01
Keywords: National In…
National Center for Biotechnology Information
NF-κB–mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia
Cachexia is a debilitating condition characterized by extreme skeletal muscle wasting that contributes significantly to morbidity and mortality. Efforts to elucidate the underlying mechanisms of muscle loss have predominantly focused on events intrinsic to the myofiber. In contrast, less regard has ...
Author: Wei A. He, Em…
Published: 2013/11/11
Publication: J Clin Inv…
ScienceDirect
Review PAX3 and PAX7 as upstream regulators of myogenesis
Like other subclasses within the PAX transcription factor family, PAX3 and PAX7 play important roles in the emergence of a number of different tissues during development. PAX3 regulates neural crest and, together with its orthologue PAX7, is also expressed in parts of the central nervous system. In ...
Published: 2015/08/01
Cited By: 0
Keywords: Pax3; Pax7…
National Center for Biotechnology Information
PAX3/7 EXPRESSION COINCIDES WITH MYOD DURING CHRONIC SKELETAL MUSCLE OVERLOAD
Paired box (Pax) proteins 3 and 7 are key determinants for embryonic skeletal muscle development by initiating myogenic regulatory factor (MRF) gene expression. We show that Pax3 and 7 participate in adult skeletal muscle plasticity during the initial responses to chronic overload (≤7 days) and appe...
Author: Jon-Philippe K…
Published: 2008/07
DOI: 10.1002/mus.21006
PubMed
PAX7 and MyoD Proteins Expression in Response to Eccentric and Concentric Resistance Exercise in Active Young Men
Objective: Satellite cells play an important role in muscle regeneration, which this process can be affected by different genes including PAX7 and MyoD. Exercise training known as an important strategy for mediating the satellite cell's function. Therefore, the main purpose of the present study is t...
Author: Somayeh Kari…
Published: 2023/02/01
Keywords: Satellite cel…
PNAS
https://www.pnas.org › doi
Pax7 is critical for the normal function of satellite cells …
Here, we demonstrate that Pax7 expression is an absolute prerequisite for the normal function of satellite cells during regenerative myogenesis at any age. Our experiments therefore demonstrate that Pax7 plays an essential role in …
Cell Press
https://www.cell.com › fulltext
Pax7 Is Required for the Specification of Myogenic …
Sep 15, 2000 · The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in …
Author: Patrick Seale, Luc A Sabourin, Adele Girgis-Gabardo, Ahmed Mansouri, Peter Gruss, Michael A Rudnicki
Publish Year: 2000
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
PAX7 and MyoD Proteins Expression in Response to Eccentric and ...
We observed that the PAX7 protein expression level increased significantly after eccentric (47.75%) and concentric (39.21%) (P=0.01) intervention. While, the MyoD protein expression …
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What is the difference between PAX7+ & MyoD+ cells?
Pax7+/MyoD+ cells are activated satellite cells that express myogenic factors and permit the cells to differentiate and proliferate, whereas Pax7−/MyoD+ cells are differentiating cells that are also controlled by other MRFs . The symmetric expression pattern quantification is also often quantified using Pax7 and Myf5 instead of MyoD.
PAX7, a Key for Myogenesis Modulation in Muscular Dystrophies throu…
pmc.ncbi.nlm.nih.gov
Does PAX7 Act genetically upstream of MyoD?
Constitutive Pax7 expression in a Pax7-null C2C12 subclone increased the proportion of cells expressing MyoD, showing that Pax7 can act genetically upstream of MyoD. However these Pax7-null cells were unable to differentiate into normal myotubes in the presence of Pax7.
Pax7 and myogenic progression in skeletal muscle satellite cells
pubmed.ncbi.nlm.nih.gov
Does PAX7 regulate regenerative myogenesis?
Here, we demonstrate that Pax7 expression is an absolute prerequisite for the normal function of satellite cells during regenerative myogenesis at any age. Our experiments therefore demonstrate that Pax7 plays an essential role in regulating the myogenic potential and function of satellite cells.
Pax7 is critical for the normal function of satellite cells in adult
pnas.org
Where is PAX7 expressed?
In adult muscle, Pax7 is expressed by the majority of quiescent satellite cells (Seale et al., 2000), whereas Pax3 is only present in satellite cells in particular muscles (Relaix et al., 2006), although it has been reported that Pax3 is transiently expressed in satellite cells during activation (Conboy and Rando, 2002).
Pax7 and myogenic progression in skeletal muscle satellite cells
journals.biologists.com
Does PAX7 regulate the myogenic potential and function of satellite cells?
Our experiments therefore demonstrate that Pax7 plays an essential role in regulating the myogenic potential and function of satellite cells. Extensive analyses of mice carrying null mutations in paired box 7 (Pax7) have confirmed the progressive loss of the satellite cell lineage in skeletal muscle, resulting in severe muscle atrophy and death.
Pax7 is critical for the normal function of satellite cells in adult
pnas.org
Does PAX7 suppress MyoD?
A recent suggestion that Pax7 has a role in self-renewal by suppressing MyoD and causing cells to exit the cell cycle (Olguin and Olwin, 2004), is inconsistent with a series of observations that Pax genes have a positive role in proliferation in many tissues (Mansouri et al., 1999).
Pax7 and myogenic progression in skeletal muscle satellite cells
journals.biologists.com
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
NF-κB–mediated Pax7 dysregulation in the muscle …
Nov 1, 2013 · Overexpression of Pax7 was sufficient to induce atrophy in normal muscle, while under tumor conditions, the reduction of Pax7 or exogenous addition of its downstream target, …
- Author: Wei A. He, Emanuele Berardi, Veronica M. Cardillo, Swarnali Acharyya, Paola Aulino, Jennifer Thomas-...
- DOI: 10.1172/JCI68523
- Publish Year: 2013
- Published: 2013/11/11
nih.gov
https://www.ncbi.nlm.nih.gov › pmc › articles
PAX3/7 EXPRESSION COINCIDES WITH MYOD DURING CHRONIC …
We show that Pax3 and 7 participate in adult skeletal muscle plasticity during the initial responses to chronic overload (≤7 days) and appear to coordinate MyoD expression, a member of the …
Science | AAAS
https://www.science.org › doi
Integrative molecular roadmap for direct conversion of …
Apr 6, 2022 · Furthermore, we demonstrate via this system that subjecting fibroblasts to MyoD+F/R/C treatment forms heterogeneous iMPC cultures consisting of proliferative Pax7 + cells that can propagate without ectopic …
biologists.com
https://journals.biologists.com › jcs › article
Pax7 and myogenic progression in skeletal muscle …
May 1, 2006 · Quiescent satellite cells express the transcription factor Pax7 and when activated, coexpress Pax7 with MyoD. Most then proliferate, downregulate Pax7 and differentiate. By contrast, others maintain Pax7 but lose MyoD and …
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PAX7, a Key for Myogenesis Modulation in Muscular …

Pax7 and myogenic progression in skeletal muscle satellite cells

Marking the tempo for myogenesis: Pax7 and the regulation of …

Pax7 is critical for the normal function of satellite cells …

Pax7 Is Required for the Specification of Myogenic …

PAX7 and MyoD Proteins Expression in Response to Eccentric and ...

PAX7, a Key for Myogenesis Modulation in Muscular Dystrophies throu…

Pax7 and myogenic progression in skeletal muscle satellite cells

Pax7 is critical for the normal function of satellite cells in adult

Pax7 and myogenic progression in skeletal muscle satellite cells

Pax7 is critical for the normal function of satellite cells in adult

Pax7 and myogenic progression in skeletal muscle satellite cells

NF-κB–mediated Pax7 dysregulation in the muscle …

PAX3/7 EXPRESSION COINCIDES WITH MYOD DURING CHRONIC …

Integrative molecular roadmap for direct conversion of …

Pax7 and myogenic progression in skeletal muscle …

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