Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly [ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. [5] . It is the most abundant of the PARP family of enzymes, …

Poly (ADP-ribose) polymerase 1 (PARP1), the best-studied isoform of the nuclear enzyme PARP family, plays a pivotal role in cellular biological processes, such as DNA repair, gene transcription, and so on. PARP1 has been found to be overexpressed in various carcinomas.

Jul 5, 2017 · PARP1 is an abundant nuclear protein that post-translationally attaches a negatively charged polymer termed poly (ADP-ribose) (PAR) to itself and to multiple target proteins.

Mar 30, 2025 · PARP1 (Poly (ADP-Ribose) Polymerase 1) is a Protein Coding gene. Diseases associated with PARP1 include Diphtheria and Fallopian Tube Carcinoma. Among its related pathways are Apoptosis and survival FAS signaling cascades and Transcription-Coupled Nucleotide Excision Repair (TC-NER).

PARP1 was first described by its role in the repair of alkylating agent-induced DNA base damages and also single strand breaks (SSBs). PARP1 is involved in base excision repair (BER) via recruitment of BER scaffold protein XRCC1 (X-ray cross-complementing group 1) …

Poly(ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, including the base excision repair (BER), non-homologous end joining (NHEJ), homologous recombination (HR), and Okazaki-fragment processing …

Apr 1, 2025 · This review presents a comprehensive overview of PARP1 biological features and mechanisms, its role in cancer development, therapeutic implications, and emerging cancer treatments by PARPi-mediated therapies.

May 28, 2024 · Poly (ADP-ribose) polymerase 1 (PARP1), also known as ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1), is the founding and most widely studied member of the ARTD family, which consists of 17 proteins in human cells. 1 PARP1 serves as a DNA damage sensor that binds to both single-strand DNA breaks (SSBs) and double-strand DNA breaks (DSBs)...

Feb 8, 2025 · PARP1 expression predicts PARP inhibitor sensitivity and correlates with metastatic potential and overall survival in melanoma. Functional genetic variation in 3'UTR of PARP1 indicates a decreased risk and a better severity of ischemic stroke. The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation.

Sep 3, 2020 · Poly (ADP-ribose) polymerase 1 (PARP1) cleaves NAD + to ADP-ribose and nicotinamide, and covalently attaches ADP-ribose to an acceptor protein. Additional NAD + molecules can be cleaved and...