Dec 17, 2024 · Parkin KO exhibit largely normal brain morphology (Goldberg et al., 2003). At 12, 18, and 24 months of age, the number of tyrosine hydroxylase (TH)-positive neurons did not …

Oct 26, 2005 · Interestingly, it is known that the dopamine content significantly decreases in PD brains. Therefore, the role of dopamine in parkin solubility in vivo, and the functional …

Parkin-Q311X mice (line A) have two copies of the transgene (Tg) integrated in tandem in a bacterial artificial chromosome (BAC), although its integration site is unknown. Notably, as …

Mar 14, 2025 · From this perch, PINK1’s kinase domain springs into action, phosphorylating ubiquitin, which recruits the ubiquitin ligase Parkin—another PD-linked protein—to tag …

Sep 5, 2013 · AIMP2/p38 is one of more than twenty putative Parkin substrates reported in the literature; a number of them have been shown to cause dopaminergic neurodegeneration in in …

Phosphorylation of Parkin and ubiquitin at serine 65 was also lost in cortical KI cells following A/O treatment. Together, these results indicate that PINK1-dependent phosphorylation of Parkin at …

Jan 8, 2018 · However, basal levels of dopamine metabolites decreased with age in parkin KO rats, showing lower levels at 12 months of age than 8 months for both 3,4 …

Sep 21, 2015 · Parkin, on the other hand, seems to amplify the mitophagy signal by generating more ubiquitin substrate for PINK1 to phosphorylate, as opposed to being indispensable for …

Jan 24, 2025 · Overview. Name: Bemdaneprocel Synonyms: BRT-DA01, MSK-DA01 Therapy Type: Other Target Type: Other Neurotransmitters , Other Condition(s): Parkinson's Disease …

Parkin Q311X: Parkin-Q311X mice have bacterial artificial chromosome (BAC)-mediated expression of mutant parkin in dopaminergic neurons. The promoter and regulatory regions of …