PAK4 regulates cellular processes by its scaffolding activity and/or by phosphorylation of effector substrates, which in-turn, set-up a cascades of biochemical events cumulating into a cellular …

We investigated the effects of PAK4 signaling on hepatic ischemia/reperfusion (I/R) injury. Approach and results: Hepatocyte- and myeloid-specific Pak4 knockout (KO) mice and their …

Aug 10, 2024 · We demonstrate that PAK4 promotes insulin resistance by phosphorylating AMPKα2 at Ser491, thereby inhibiting AMPK activity. We additionally show that skeletal …

Feb 8, 2025 · PAK4 downregulation decreased PPARgamma-mediated Nox1 expression and suppressed EMT in IR-treated glioma cells. miR-1271/Zic2/PAK4 axis plays an important role …

Sep 9, 2017 · Our results provide the first evidence of a novel role for PAK4 in IR-induced EMT and suggest potential therapeutic efficacy of targeting PAK4 to overcome radioresistance in …

Aug 17, 2023 · Here, we report that oncoprotein p21-activated kinase 4 (PAK4) is an NCoR1 kinase. Specifically, PAK4 phosphorylates NCoR1 at T1619/T2124, resulting in an increase in …

Sep 14, 2017 · We identified grade-dependent p21-activated kinases 4 (PAK4) upregulation in gliomas and further determined its role in mesenchymal transition and radioresistance. IR …

Sep 1, 2021 · PAK4 overexpression is a predictive biomarker for tumor development and resistance to cancer treatments. PAK4 is also a regulator of the anti-tumor immune response. …

Jan 1, 2023 · Furthermore, ionizing radiation therapy (IR) was also reported that ionizing radiation (IR) therapy significantly increase PAK4 expression of PAK4 and nuclear localization, as well …

Oct 1, 2022 · In this paper, we systematically review the role of PAK4 in cancer, including its structure, localization, expression, upstream regulators and essential functions in cancer. We …