PAK3 (p21-activated kinase 2, beta-PAK) is one of three members of Group I PAK family of evolutionary conserved serine/threonine kinases. [5] [6] [7] PAK3 is preferentially expressed in neuronal cells [8] [9] and involved in synapse formation and …

Mar 30, 2025 · PAK3 (P21 (RAC1) Activated Kinase 3) is a Protein Coding gene. Diseases associated with PAK3 include Intellectual Developmental Disorder, X-Linked 30 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Signaling by Rho GTPases and Integrin Pathway.

The PAK family consists of six members and divided into two groups, group I (PAK1, PAK2, and PAK3) and group II (PAK4, PAK5, and PAK6). PAK5 is sometimes referred to as PAK7. The PAK gene sequences and their structures are conserved from amoeba, yeast, Caenorhabditis elegans, Xenopus, to human (Kumar et al., 2009).

PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.

Mar 7, 2024 · We showed that interneurons expressing a constitutively kinase active PAK3 variant (PAK3-ca) extended shorter leading processes and exhibited unstable polarity. In the upper cortical layers,...

Jan 4, 2025 · Title: PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.

Oct 25, 2021 · A recent study evaluating 155 AML patient samples found that high PAK3 and PAK5 were associated with poor event-free survival (EFS) and OS . In contrast, patients with high PAK2 levels ...

HGNC Approved Gene Symbol: PAK3. Ras (HRAS; 190020)-related GTPases, or p21 proteins, of the Rho (RHOA; 165390) subfamily are critical regulators of signal transduction pathways. The p21-activated kinases (PAKs) are a family of serine/threonine kinases that are central to signal transduction and cellular regulation.

Mar 1, 2020 · We identified a novel missense G424R mutation in the X-linked p21-activated kinase 3 (PAK3) gene in a boy presenting with severe ID, microcephaly and CCA and his fetal sibling with CCA and severe hydrocephaly.

Oct 10, 2024 · Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells. PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.