PAK2 signaling modulates apoptosis, [10] endothelial lumen formation, [11] viral pathogenesis, [12] and cancer including, breast, [13] hepatocarcinoma, [14] gastric [15] and cancer, at-large, [16] and, based on its kinase activity alone, peripheral …

Mar 30, 2025 · PAK2 (P21 (RAC1) Activated Kinase 2) is a Protein Coding gene. Diseases associated with PAK2 include Knobloch Syndrome 2 and Knobloch Syndrome. Among its related pathways are Signaling by Rho GTPases and Autodegradation of the E3 ubiquitin ligase COP1.

This review provides a comprehensive overview of PAK2's role in cancer, focusing on its involvement in processes such as angiogenesis, metastasis, cell survival, metabolism, immune response, and drug resistance.

In this review, we discuss the mechanisms of Pak activation in cancer, the key substrates for this family of kinases that mediate their developmental and oncogenic effects, and how small molecule inhibitors of these enzymes might best be developed and deployed in the treatment of cancer.

Feb 1, 2025 · PAK2 plays a key role in regulating T cell maturation and differentiation. Studies show that the absence or dysfunction of PAK2 disrupts the production of essential receptor proteins during T cell maturation, resulting in impaired T cell function and enabling tumor cells to evade immune surveillance (Fig. 3 B) [49]. Specifically, PAK2 ...

Oct 25, 2021 · PAK2 facilitates STAT5 translocation in CML as well, and drives the Rac-PAK-Cofilin pathway, leading to increased ROS production.

PAK2, a gene frequently amplified in adult T-Cell Leukemia/Lymphoma (ATLL), facilitates CADM1-mediated stromal interaction and promotes survival of ATLL cells. The pan-PAK inhibitor PF-3758309 (PF) has strong in vitro and in vivo activity in a variety of ATLL preclinical models.

Jan 10, 2025 · Heart failure with preserved ejection fraction (HFpEF) is linked to prolonged endoplasmic reticulum (ER) stress. P21‐activated kinase 2 (Pak2) facilitates a protective ER stress response. This study explores the mechanism and role of Pak2 in HFpEF pathology.

Jun 3, 2019 · Here, we demonstrate that E-cadherin responds to force by recruiting and activating p21-activated protein kinase 2 (PAK2) to allow cells to stiffen, metabolize, and survive. Interestingly, PAK2 activation and its control of the apoptotic response are specific for the amplitude of force applied.

Feb 22, 2023 · We demonstrated that PAK2’s interaction with PLK1 protected it from degradation by APC/C Cdh1, and that it promoted meiotic progression and bipolar spindle formation. Our data collectively...