p21‐activated kinase 1 (Pak1) is a member of the highly conserved family of serine/threonine protein kinases regulated by Ras‐related small G‐proteins, Cdc42/Rac1. It has been previously demonstrated to be involved in cardiac protection.

PAK1 is required for hepatocyte growth factor (HGF)-induced actin dynamics and proliferation of squamous NSCLC cells. EBC-1 cells were pretreated with Dox for 3 days prior to serum starvation for 16 hours and treatment with 50 ng/mL HGF for 1 hour.

p21-activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers and neurological disorders, and its tractability as a target for small-molecule inhibition.

PAK1 is one of six members of the PAK family of serine/threonine kinases which are broadly divided into group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK6 and PAK5/7). [7] [8] The PAKs are evolutionarily conserved. [9] PAK1 localizes in distinct sub-cellular domains in the cytoplasm and nucleus. [10]

Mar 8, 2025 · HIV-1 Tat induces actin cytoskeletal rearrangements through p21-activated kinase 1 (PAK1) and downstream activation of the endothelial NADPH oxidase, an effect that is lost by introduction of mutations into the Tat cysteine-rich or basic domains

Mar 30, 2025 · PAK1 (P21 (RAC1) Activated Kinase 1) is a Protein Coding gene. Diseases associated with PAK1 include Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay and Neurofibromatosis. Among its related pathways are EPH-Ephrin signaling and Semaphorin interactions.

PAK1, a protein kinase, plays a crucial role in intracellular signaling pathways downstream of integrins and receptor-type kinases. It is involved in a wide range of cellular processes, including cytoskeleton dynamics, cell adhesion, migration, proliferation, apoptosis, mitosis, and vesicle-mediated transport.

Based on recent studies, this review provides an overview of the role of Pak1 in cardiac diseases including disrupted Ca 2+ homoeostasis-related cardiac arrhythmias, adrenergic stress- and pressure overload-induced hypertrophy, and ischaemia/reperfusion injury.

Nov 17, 2022 · Exosomal miR-485-3p delivered by normal pancreatic ductal epithelial cells into PC cells inhibits PC metastasis by directly targeting PAK1. The restoration of miR-485-3p by exosomes or some other vehicle might be a novel approach for PC treatment.

PAK1 is a promising therapeutic target in cancer and allergen-induced disorders. Its suitability as a target in vascular, neurological and infectious diseases remains ambiguous.