p21-Activated kinase 1 (PAK1) in aging and longevity: An overview
This review describes PAK family proteins, their biological functions, and their role in regulating aging and longevity using C. elegans. Moreover, we discuss the effect of small-molecule PAK1 …
- Author: Mohankumar Amirthalingam, Sundararaj Palanisamy, Shinkichi Tawata
- Publish Year: 2021
Targeting PAK1 - PMC
p21-activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers and neurological disorders, and its …
PAK1 p21 (RAC1) activated kinase 1 [ Homo sapiens (human) ]
Mar 8, 2025 · This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to …
p21-activated kinase 1: PAK'ed with potential - PMC
The p21-activated kinases (PAKs) are central players in growth factor signaling networks and morphogenetic processes that control proliferation, cell polarity, invasion and actin …
P21-Activated Kinase 1: Emerging biological functions and …
Aug 1, 2020 · Here, we provide an overview of essential roles that PAK1 plays in cancer, including its structure and autoactivation mechanism, its crucial function from onset to …
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PAK1 Gene - GeneCards | PAK1 Protein | PAK1 Antibody
Mar 30, 2025 · This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, …
p21-Activated Kinase 1 (Pak1) as an Element in Functional and ...
Mar 10, 2025 · This review focuses on p21-activated kinase 1 (Pak1), a multifunctional, highly conserved enzyme that regulates multiple downstream effectors present in many tissues. …
The p21-activated kinase (PAK1) is involved in diet-induced beta …
A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic beta cells. Biochem Pharmacol. 2013;85:808–816. doi: …
Development of p21 activated kinase-targeted multikinase …
We report the development of two new PAK-inhibiting compounds that were modified from the structure OSU-03012, a previously identified multikinase inhibitor that competitively blocks …
