Mar 30, 2025 · PABPC1 (Poly(A) Binding Protein Cytoplasmic 1) is a Protein Coding gene. Diseases associated with PABPC1 include Rift Valley Fever and Dengue Virus . Among its related pathways are Peptide chain elongation and Nervous system development .

Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene. [5] The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability.

The PABPC1 gene, originally isolated and cloned in human melanoma cells by Grange et al. in 1978, is conserved throughout eukaryotes and is located on human chromosome 8 (31, 32). PABPC1 consists of four RNA binding domains (RRM1-4), a linker region and a …

Mar 18, 2025 · In this Article we utilize unbiased genetic screens to map the relationship of RBP expression with accelerated protein synthesis in CML-BC, identifying poly (A) binding protein cytoplasmic 1...

Mar 16, 2025 · HIV-1 Rev interacting protein, poly (A) binding protein 1 (PABPC1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PABPC1 is increased by RRE. HIV-1 PR-induced PABP cleavage is involved in the inhibition of poly (A)-dependent translation.

Jun 20, 2024 · In the H9 nucleus, newly produced (A)-rich circRNAs are bound by PABPC1 and trapped by the nuclear basket protein TPR to prevent their export. Modulating (A)-rich motifs in circRNAs alters their subcellular localization, and introducing (A)-rich circRNAs in H9 cytosols results in mRNA translation suppression.

In this study, we report that hnRNPLL specifically associates with cytoplasmic PABPC1 (poly (A)-binding protein 1) in both T cells and plasma cells.

PABPC1 silencing increased AZGP1 and ARHGAP30 expression and decreased CAV1 and COL12A1 expression in BXPC3 cells. PABPC1 positively mediated COL12A1 expression, whereas PABPC1 knockdown induced the inhibition of …

Mar 5, 2024 · Clinical resource with information about PABPC1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Dec 1, 2022 · In this paper, we review the abnormal expression, functional role, and molecular mechanism of PABPC1 in tumorigenesis and provide directions for further understanding the regulatory role of PABPC1 in tumor cells.