In patients with suspected TMA, urinary PU/CU on admission ≤ 1.5 g/g and/or a FS = 2 is a quick and simple criterion by which to suggest TTP rather than HUS, enabling the rapid initiation of targeted therapies.

Jan 27, 2022 · Conclusions: The addition of urinary PU/CU upon admission of patients with TMA is a fast and readily available test that can aid in the differential diagnosis of TTP versus HUS alongside traditional scoring. Keywords: diagnosis; differential; hemolytic-uremic syndrome; proteinuria; purpura; thrombotic microangiopathies; thrombotic thrombocytopenic.

Sep 24, 2024 · Thrombotic microangiopathy involves tiny clots forming within the microvasculature. This leads to erythrocyte fragmentation (which is termed MAHA: microangiopathic hemolytic anemia). Occlusion of the microvasculature also leads to …

Jan 17, 2025 · Thrombotic microangiopathy (TMA) is a clinical syndrome characterized by endothelial injury and thrombotic occlusion of the microvasculature, leading to end-organ damage. This systemic disorder can affect any organ system, including the brain, heart, and gastrointestinal tract. However, the kidney is the most frequently affected organ.[1]

Nov 2, 2023 · Transplant-associated TMA (TA-TMA) can occur as a complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The mechanism of TA-TMA is not fully understood, and conventional treatment options are based on targeting the identified risk factors and hypothesized pathophysiology.

Sep 30, 2022 · Patients/Methods: In a retrospective study, in association with the “French Score” (FS) (platelets < 30 G/L and serum creatinine level < 200 µmol/L), we assessed PU/CU for the diagnosis of TTP in patients above the age of 15 with thrombotic microangiopathy (TMA).

Thrombotic microangiopathy (TMA) is a serious complication that may occur in patients with systemic lupus erythematosus (SLE), adversely affecting the prognosis and increasing mortality. The pathogenesis of TMA in these patients may be multifactorial and overlap between different entities may exist.

Mar 21, 2022 · Transplantation-associated thrombotic microangiopathy (TA-TMA) can range from a self-limiting condition to a lethal transplantation complication. It is important to identify TA-TMA patients at risk for severe multiorgan endothelial injury to …

In Pennsylvania, the Pennsylvania Uniform Transfers to Minors Act (PUTMA), 20 Pa. C.S.A.§§ 5301 to 5320, provides an inexpensive easy mechanism for giving property to minors. Under this Act, the custodian can invest the funds, and apply them as …

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