Pentraxin-related protein PTX3 also known as TNF-inducible gene 14 protein (TSG-14) is a protein that in humans is encoded by the PTX3 gene. [5] [6] Pentraxin 3 (ptx3) is a member of the pentraxin superfamily. This super family characterized by cyclic multimeric structure. [7]

Mar 30, 2025 · PTX3 (Pentraxin 3) is a Protein Coding gene. Diseases associated with PTX3 include Atypical Hemolytic-Uremic Syndrome and Acute Chest Syndrome . Among its related pathways are Innate Immune System and Complement cascade .

Furthermore, PTX3 broadly impacts the adhesion molecule P-selectin, which is known to play distinct roles in atherogenesis. PTX3 brings about downregulation of P-selectin-dependent neutrophil recruitment to inflammatory sites and of P …

Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 was initially isolated from human umbilical vein endothelial cells and human FS-4 fibroblasts.

The long pentraxin PTX3 is a prototypic humoral pattern recognition molecule that, in addition to providing defense against infectious agents, plays several functions in tissue repair and regulation of cancer-related inflammation.

Pentraxin 3 (PTX3) is a prototypic humoral soluble pattern recognition molecule that exerts a pivotal role in innate immune response and inflammation, as well as in tissue damage and remodeling.

Jun 21, 2021 · PTX3 is a soluble pattern recognition molecule (PRM) belonging to the humoral innate immune system, rapidly produced at inflammatory sites by phagocytes and stromal cells in response to infection or tissue injury.

Pentraxin 3 (PTX3), an acute-phase inflammation protein produced by several cell types, has long been described as a possible biomarker for age-related cardiovascular and cerebrovascular diseases.

PTX3 may be a useful biomarker for diagnosis of febrile neutropenia in patients with lung neoplasms. PTX3 may be a potential novel indicator of carotid plaque vulnerability. PTX3 is able to modulate the innate response to gliadin in celiac disease and it could regulate the adaptive immune response.

Jul 1, 2017 · Our preliminary findings highlight the capability of human osteoblasts to express PTX3 both in vivo and in vitro models. Noteworthy, the expression of PTX3 appears significantly reduced in osteoblasts that showed a poor propensity to form hydroxyapatite crystals, especially in osteoporotic patients.