Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine phosphatases. This protein …

Mar 30, 2025 · PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) is a Protein Coding gene. Diseases associated with PTPN22 include Rheumatoid Arthritis and Systemic …

PTPN22, a member of the protein tyrosine phosphatase (PTP) superfamily that downregulates T cell signaling and proliferation, has recently emerged as a systemically druggable and novel …

Feb 8, 2025 · PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling. Autoimmunity linked protein phosphatase PTPN22 as a target for cancer …

The PTPN22 gene provides instructions for making a protein that belongs to the PTP (protein tyrosine phosphatases) family. PTP proteins play a role in regulating a process called signal …

A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus …

This review describes the basics of PTPN22 structure and function and provides comprehensive insight into recent advances in small molecule PTPN22 inhibitor development and the …

PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signalling and by …

Feb 8, 2025 · PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells. PTPN22 deficiency resulted in pronounced colitis, increased …

Jul 8, 2014 · PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signalling …