- PTPN2 encodes a phosphatase responsible for the negative regulation of JAK/STAT signaling. Speci fically, PTPN2 dephosphorylates JAK and STAT proteins, resulting in the cessa-tion of STAT transcriptional activity and general dampening of in flammatory re-sponses (Stanford and Bottini, 2023).rupress.org/jem/article-pdf/221/9/e20240980/1930795/jem_20240980.pdf
PTPN2 deficiency: Amping up JAK/STAT - PMC
PTPN2 encodes a phosphatase responsible for the negative regulation of JAK/STAT signaling. Specifically, PTPN2 dephosphorylates JAK and STAT proteins, resulting in the cessation of …
The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier ... - PubMed
Mar 5, 2021 · PTPN2 regulates Janus-kinase [JAK] and signal transducer and activator of transcription [STAT] signalling, while protecting the intestinal epithelium from inflammation …
- Author: Marianne R Spalinger, Anica Sayoc-Becerra, Christ Ordookhanian, Vinicius Canale, Alina N Santos, Ste...
- Publish Year: 2021
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti …
Oct 4, 2023 · Here we present the discovery and characterization of ABBV-CLS-484 (AC484), a first-in-class, orally bioavailable, potent PTPN2 and PTPN1 active-site inhibitor. AC484 …
PTPN2, A Key Predictor of Prognosis for Pancreatic …
Among these members, PTPN2 is the most important prognostic signature that regulates the progression of PAAD by activating JAK-STAT signaling pathway. Comparison of two PAAD cell lines with normal pancreatic epithelial cell lines …
Protein tyrosine phosphatase non-receptor type 2 as the …
PTPN2 is a negative regulator of the JAK/STAT signaling and inhibits its activation and transfer to the nucleus by dephosphorylation of several of its members, such as JAK1/3 and STAT1/3.
Loss-of-Function Mutation in PTPN2 Causes Aberrant …
Apr 20, 2020 · The very recent identification of monoallelic loss-of-function PTPN2 mutation in a young man presenting with common variable …
- Author: Marianna Parlato, Qing Nian, Qing Nian, Fabienne Charbit-Henrion, Fabienne Charbit-Henrion, Frank M....
- Publish Year: 2020
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PTPN2 negatively regulates oncogenic JAK1 in T-cell acute
Jun 30, 2011 · Our results reveal that some JAK1 mutation-positive T-ALLs harbor deletions of the tyrosine phosphatase PTPN2, a known negative regulator of the JAK/STAT pathway. We …
PTPN2 encodes a phosphatase responsible for the negative regulation of JAK/STAT signaling. Speci fically, PTPN2 dephosphorylates JAK and STAT proteins, resulting in the cessa-tion of …
Regulation of protein phosphorylation by PTPN2 and its small …
Nov 5, 2024 · PTPN2 is a protein tyrosine phosphatase that negatively regulates JAK/STAT and PTK signaling pathways. PTPN2 deficiency enhances the responsiveness of T-ALL cells to …
Loss-of-Function Mutation in PTPN2 Causes Aberrant Activation of JAK …
Loss-of-Function Mutation in PTPN2 Causes Aberrant Activation of JAK Signaling Via STAT and Very Early Onset Intestinal Inflammation Gastroenterology . 2020 Nov;159(5):1968-1971.e4. …
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