- Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B.www.genecards.org/cgi-bin/carddisp.pl?gene=PTPA
Structural basis of PP2A activation by PTPA, an ATP-dependent
Oct 8, 2013 · Our results suggest novel mechanisms of PTPA in PP2A activation with structural economy and a unique ATP-binding pocket that could potentially serve as a specific …
- Author: Feng Guo, Vitali Stanevich, Nathan Wlodarchak, Rituparna Sengupta, Li Jiang, Kenneth A Satyshur, Yon...
- Publish Year: 2014
PTPA variants and impaired PP2A activity in early-onset ... - PubMed
Apr 19, 2023 · The protein phosphatase 2A complex (PP2A), the major Ser/Thr phosphatase in the brain, is involved in a number of signalling pathways and functions, including the regulation …
PTPA variants and impaired PP2A activity in early-onset …
Sep 8, 2022 · We conclude that bi-allelic missense PTPA variants associated with impaired activation of the PP2A phosphatase cause autosomal recessive early-onset parkinsonism with …
- DOI: 10.1093/brain/awac326
- Published: 2023/04
- Publication: Brain. 2023 Apr; 146(4): 1496-1510.
Structure and Mechanism of the Phosphotyrosyl Phosphatase …
Aug 18, 2006 · Phosphotyrosyl phosphatase activator (PTPA), also known as PP2A phosphatase activator, is a conserved protein from yeast to human. Here we report the 1.9 Å crystal …
Crystal Structure of the PP2A Phosphatase Activator
Aug 4, 2006 · PTPA, an essential and specific activator of protein phosphatase 2A (PP2A), functions as a peptidyl prolyl isomerase (PPIase). We present here the crystal structures of human PTPA and of the two yeast orthologs (Ypa1 …
Identification of PP2A complexes and pathways involved in cell ...
PP2A refers to a family of phosphatases that contain a common catalytic C subunit, whose activity is regulated by a diverse set of regulatory proteins. PP2A complexes usually contain an active …
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PTPA Gene - GeneCards | PTPA Protein | PTPA Antibody
Mar 30, 2025 · PTPA (Protein Phosphatase 2 Phosphatase Activator) is a Protein Coding gene. Diseases associated with PTPA include Parkinson Disease 25, Autosomal Recessive Early-Onset, With Impaired Intellectual Development …
A novel and essential mechanism determining specificity and …
Sep 1, 2003 · Here we report a novel and phylogenetically conserved mechanism to generate active phospho-serine/threonine-specific PP2A in vivo. Phosphotyrosyl phosphatase activator …
Phosphatase: PP2A structural importance, regulation and its …
Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules …
PTPA Regulating PP2A as a Dual Specificity Phosphatase
This phosphotyrosyl phosphatase activator or PTPA was shown to be highly specific for the dimeric form of PP2A (PP2A D) . PTPA stimulates the PTPase activity of PP2A D in a time …
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