Ectopic expression of wild-type PTEN in myeloid leukemia cells restored cytokine responsiveness at physiological concentrations of GM-CSF (<0.02 ng/mL) and significantly improved cell sensitivity to MAPK inhibitor.

Feb 18, 2022 · The tumor suppressor gene, PTEN, plays a key role regulating both phosphoinositide 3-kinases/AKT/mTOR (phosphoinositide 3-kinases) and RAF/MEK/ERK (MAPK) signaling pathways. 2 Loss of PTEN function, therefore, will result in activation of both pathways leading to cell proliferation and increased angiogenesis.

Apr 1, 2012 · PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of …

Apr 1, 2012 · PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of …

Pten Loss Drives PI3K/Akt and MAPK Signaling Pathways in HER2/neu Mammary Tumors. We postulated that restoration of Pten protein in Pten knockdown tumor tissue disrupts the signaling pathways governing cellular proliferation and/or survival, leading to tumor shrinkage.

Aug 1, 2013 · Two intracellular signaling pathways, the phosphatase and tensin homolog (PTEN)/phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling cascades play various cellular roles under normal and pathological conditions.

Feb 21, 2017 · Combined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy in oncology. Since PTEN lies at the intersection of these two pathways, we investigated...

Using the roundworm C. elegans as a model to study how cells communicate during animal development, we discovered a new mechanism by which PTEN inhibits the activity of the oncogenic RAS/MAPK signaling pathway.

Oct 1, 2018 · Our data demonstrate that overexpression of PTEN suppresses both AKT and MAPK activities in myeloid leukemia cells in response to GM-CSF stimulation, and that PD98059 can inhibit MAPK activities in cells with overexpression of PTEN, but not in …

This review provides an overview of the PI3 kinase pathway focusing specifically on two members of the pathway, called PTEN and Akt3, which play important roles in melanoma development.