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Mar 20, 2025 · Progressive supranuclear palsy is characterized by decreased cognition, abnormal eye movements (supranuclear vertical gaze palsy), postural instability and falls, as well as Parkinsonian features and speech disturbances 1-3.

Apr 5, 2010 · In Parkinson disease, FDG-PET most frequently shows hypermetabolism of the dorsolateral putamen. Cerebellar hypometabolism has been reported in patients with PSP but is not specific. Predominant cerebellar together with bilateral putamen hypometabolism favors multiple system atrophy. 2

May 25, 2022 · Methods: 11 C-CFT positron emission tomography (PET) imaging was conducted in 83 PSP patients consisting of different subtypes, 61 patients with PD, 41 patients with MSA-P, and 43 healthy volunteers. Demographic and clinical data were compared by the chi-squared test or one-way analysis of variance.

Studying the clinical and MRI features of patients with PSP can be helpful in the diagnosis, especially as some signs could be found in the early stage by FDG PET, enhancing early diagnosis and differentiation.

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Jan 10, 2010 · We developed an automated image-based classification procedure to differentiate individual patients with idiopathic Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy.

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Feb 24, 2012 · There have been FDG-PET studies in the past comparing progressive supranuclear palsy (PSP) and Parkinson’s Disease patients. This German study takes the research a step further and looks at two different types of PSP.

Tau PET imaging indicates different topography of tau deposition between PSP patients and HCs or other neurodegenerative disorders. The affinity and selectivity of tracers for 4R-tau and the off-target binding of tracers should be considered when interpreting the results.