Results showed naked mAbs induced antibody-dependent cell-mediated cytotoxicity of human prostate cells; the mAb labeled with isotope 177 Lu was well tolerated and was effective in targeting PSMA and increasing survival in animals by more than 3-fold.

Increased abundance of the prostate-specific membrane antigen (PSMA) on prostate epithelium is a hallmark of advanced metastatic prostate cancer (PCa) and correlates negatively with prognosis. However, direct evidence that PSMA functionally contributes to PCa progression remains elusive.

Jul 8, 2024 · Prostate-specific membrane antigen (PSMA) is an important cell-surface imaging biomarker and therapeutic target in prostate cancer. The PSMA-targeted theranostic 177 Lu-PSMA-617 was...

Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid.

Nov 15, 2017 · Prostate cancer cells have high levels of prostate-specific membrane antigen (PSMA), but researchers were unsure of its biological role. Now an MSK-led team has discovered that PSMA contributes to prostate cancer’s development. This offers a new target for drugs.

Feb 10, 2005 · Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein, is overexpressed in prostate cancer. PSMA is a unique cell surface marker, negatively regulated by androgen and extensively used for imaging of hormone refractory carcinomas and metastatic foci.

Feb 15, 2004 · PSMA can serve as target for delivery of therapeutic agents such as cytotoxins or radionuclides. PSMA has two unique enzymatic functions, folate hydrolase and NAALADase and found to be recycled like other membrane bound receptors through clathrin coated pits.

Jul 31, 2020 · Prostate-specific membrane antigen (PSMA) is a cell surface molecule expressed at variable levels by advanced, castration-resistant prostate cancer cells. PSMA drives cancer invasion and metastasis, and high levels of PSMA serve as a marker of poor prognosis.

Prostate-specific membrane antigen (PSMA) is a membrane-bound antigen that is highly specific for benign and malignant prostatic epithelial cells. 27–36 It is present in the serum of normal men, according to studies with monoclonal antibody 7E11.C5, and an elevated concentration is associated with the presence of prostatic adenocarcinoma, clinic...

Mar 1, 2024 · Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein overexpressed in most prostate cancers and exploited as a target for PSMA-targeted therapies. Different approaches to target PSMA-expressing cancer cells have been developed, showing promising results in clinical trials.