Jun 15, 2016 · Uric acid concentration might be measured in serum, plasma, urine and in exhaled breath condensate. Determination of uric acid concentration includes phosphotungistic acid …

The catabolism of purine nucleotides results in a uric acid, which has low solubility in water and is excreted as sodium urate crystals in the urine. Allopurinol inhibits xanthine oxidase and is …

Phosphoribosylpyrophosphate synthetase superactivity (PRS superactivity) is characterized by the overproduction and accumulation of uric acid (a waste product of normal chemical …

Sep 23, 2008 · Treatment of manifestations: In all individuals, hyperuricemia and hyperuricosuria can be reduced by treatment with allopurinol or febuxostat to reduce uric acid formation and …

Lack of functioning G6Pase increases glucose-6-phosphate levels, which stimulates the pentose phosphate pathway, and consequently increases PRPP, purine biosynthesis, and uric acid. …

The treatment of PRPS1 superactivity is aimed at reducing uric acid when symptomatic. Therapies include anti-inflammatories for gout and uricosuric agents to increase renal …

Jul 2, 2003 · Overactivity of phosphoribosylpyrophosphate synthetase (PRS) is an X chromosome–linked disorder of purine metabolism that is characterized by gout with uric acid …

In the present chapter, the metabolism of PRPP will be reviewed and particular emphasis will be given to determinants of PRPP synthesis and to genetically determined biochemical …

In the pathway of purine nucleotide synthesis de novo, a series of 10 enzymatic reactions (see Chapter 1) is required for the incorporation of small molecule precur sors of uric acid into a …

We have studied families C and A in which superactivity of PRPP synthetase (E.C. 2.7.6.1) is associated with gout and uric acid overproduction in affected hemizygous males. PRPP …