Loss of function of both the p53 pathway and the retinoblastoma protein (pRB) pathway plays a significant role in the development of most human cancers. Loss of pRB results in deregulated …

Mar 31, 2022 · In the current synopsis, the mechanism of regulation by p53-p21-RB signaling is assessed and the overlap with p53-p21-DREAM signaling is examined. The tumor suppressor …

In the present study we systematically assessed the relative importance of the tumour suppressor proteins p53, p21 Waf1, pRb and p16 INK4a in mediating oncogene-induced senescence in …

This review focuses on the characteristics of senescence and on the recent advances in the contribution of p53 to cellular senescence. Moreover, we also discuss the p53-mediated …

When pRb and p53 are genetically inactivated, cells irreparably lose the antitumor mechanisms afforded by them. Cancer genome studies document recurrent genetic inactivation of RB1 and …

Feb 1, 2002 · The TP53 gene product, p53, guards against genomic instability and oncogene expression by inducing both arrest of the cell cycle and apoptosis. In contrast, the …

Dec 1, 1995 · The pRb and p53 proteins have tumour suppressor functions and both are regulators of transcription. Their mechanisms of transcriptional regulation are unrelated in …

Two fundamental molecular pathways, the pRB and p53 pathways, regulate cell growth and cell death. The importance of these pathways in cellular growth control is underscored by the …

The pRb and p53 proteins have tumour suppressor functions and both are regulators of transcription. Their mechanisms of transcriptional regulation are unrelated in many ways--in …

E6 degrades tumor suppressor p53, thus inhibiting p53-dependent functions, whereas E7 binds and degrades pRb, allowing the transcription of E2F-dependent genes.