Mar 26, 2004 · Cyclin-dependent kinases (Cdks) phosphorylate pRB and disrupt association between pRB and E2F. We investigated the effects of pRB phosphorylation on HDAC-1 …

These studies suggest that pRB regulates the local chromatin structure by recruiting HDAC1 to modulate the balance of histone acetylation levels, and HDAC inhibitors may compromise the …

Transcriptional regulation by pRB through local chromatin changes. pRB can recruit co-repressors like HDAC to E2F responsive cell cycle gene promoters to deacetylate histones and compact …

The phosphorylation of pRb by cyclin-cdk complex dissociates pRb from E2F and relieves the repression of E2F responsive genes . pRb represses E2F-mediated transcription by recruiting …

Aug 28, 2006 · It has been shown that Rb protein (pRb) is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. The retinoblastoma family includes three members, …

pRB interacts with chromatin modifying proteins known as histone deacetylases (HDAC) through this domain, either alone or through other proteins in a complex (Talluri and Dick 2012). These …

May 1, 1998 · The retinoblastoma tumour-suppressor protein (pRb) inhibits progression through the G1 phase of the mammalian cell cycle. pRb acts by inhibiting the expression of cell-cycle …

Mar 26, 2004 · We investigated the effects of pRB phosphorylation on HDAC-1 binding in vitro. Phosphorylation of pRB by Cdk4-cyclin D2, Cdk2-cyclin E, and Cdk2-cyclin A inhibited …

Feb 18, 2011 · CDK-mediated phosphorylation of pRb alleviates this inhibitory effect to promote G (1)-S phase cell cycle progression. pRb represses transcription by binding to the E2F …

Apr 4, 2002 · In this study, we have investigated promoter occupancy in wild-type and pocket protein-deficient primary cells. We show that corepressor complexes consisting of histone …