While the pentose phosphate pathway does involve oxidation of glucose, its primary role is anabolic rather than catabolic. The pathway is especially important in red blood cells (erythrocytes). The reactions of the pathway were elucidated in the early 1950s by Bernard Horecker and co-workers. [2][3] There are two distinct phases in the pathway.

Sep 2, 2023 · In this study, we propose a computational model that integrates glycolysis, the pentose phosphate pathway (PPP), the fatty acids beta-oxidation, and the tricarboxylic acid cycle (TCA cycle)...

Dec 1, 2021 · Here, exemplifying the oxidative and non-oxidative arms of the pentose phosphate pathway (PPP), we separate the roles of key metabolites or precursors generated within, and their roles in the organizations of distinct metabolic networks to drive cell growth.

While metabolism of 13 C-labeled glucose via the PPP does not appear to contribute to the production of releasable lactate, it contributes to labeling of tricarboxylic acid (TCA) cycle intermediates and related amino acids.

Glycolysis and the pentose phosphate pathway are part of central carbon metabolism and critical for energy production. Glucose is converted into important intermediates that feed into downstream metabolic pathways, including the TCA cycle and oxidative phosphorylation.

In this study, we propose a computational model that integrates glycolysis, the pentose phosphate pathway (PPP), the fatty acids beta‐oxidation, and the tricarboxylic acid cycle (TCA cycle) using...

Apr 21, 2023 · Therefore, recent studies have focused on the global regulation of metabolic flux, looking for breakthroughs in the most fundamental metabolic pathway, central carbon metabolism (CCM), which includes glycolysis, the tricarboxylic acid cycle (TCA cycle), and the pentose phosphate pathway (PPP).

Dec 20, 2022 · Metabolic reprogramming of cancer cells is a hallmark of cancer, in which the polar metabolites involving aerobic glycolysis, pentose phosphate pathway (PPP), tricarboxylic acid (TCA) cycle, and glutaminolysis play a crucial role in …

The central carbon metabolism (glycolysis, the pentose phosphate pathway [PPP], and the tricarboxylic acid [TCA] cycle) plays an essential role in the supply of biosynthetic precursors and energy.

Glucose is a main carbon and energy source for virus proliferation and is usually involved in the glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid cycle (TCA cycle) pathways. In this study, we investigated the roles of ...