Proton pump inhibitors (PPIs), followed by histamine 2 receptor antagonists (H2RAs), are the most commonly used drugs to prevent gastrointestinal bleeding in critically ill patients through stress ulcer prophylaxis. The relative efficacy and drug-related adverse events of PPIs and H2RAs remain unclear.

Oct 19, 2021 · H2 blockers and PPIs both help reduce the amount of stomach acid your body produces. But there are some key differences between the two. Read on to learn more. How do h2 blockers work? H2 receptor blockers bind to the histamine type 2 receptor in the stomach. This reduces the amount of acid that your stomach lining secretes.

When a PPI and H2 RA were administered concomitantly 30 minutes before breakfast, the H2 RA did not decrease the acid suppressive ability of the PPI; rather, it improved gastric acid control. Thus these results failed to support the initial hypothesis of this study.

Recently, the Proton Pump Inhibitors (PPIs) vs. Histamine-2 Receptor Blockers for Ulcer Prophylaxis Therapy in the Intensive Care Unit (PEPTIC) trial suggested PPIs might increase mortality. We performed an updated meta-analysis to further inform discussion.

This study compares the different side effects of PPIs and H2RAs. Most studies concluded that omeprazole is superior in healing ulcers and bringing pain relief and that patients resistant to H2RAs can be treated better when switched to a PPI.

Apr 17, 2023 · Proton pump inhibitors (PPIs) reduce the production of acid by the stomach. They work by irreversibly blocking an enzyme called H+/K+ ATPase which controls acid production.

Jan 22, 2020 · What are the comparative rates of mortality and upper gastrointestinal bleeding (UGIB) among intensive care unit (ICU) patients receiving proton-pump inhibitors (PPIs) versus histamine-2 receptor blockers (H 2 RBs) for stress ulcer prophylaxis in the PEPTIC trial?

Based on the mean 24-h gastric pH, the relative potencies of the five PPIs compared to omeprazole were 0.23, 0.90, 1.00, 1.60, and 1.82 for pantoprazole, lansoprazole, omeprazole, esomeprazole, and rabeprazole, respectively.

Oct 15, 2020 · This study aimed to investigate the risk of osteoporotic fractures in PPI users compared to histamine-2 receptor antagonist (H2RA) users and the association between fractures and the duration and regular use of PPI.

May 31, 2024 · Proton pump inhibitors (PPIs) effectively block gastric acid secretion by irreversibly binding to and inhibiting the hydrogen-potassium ATPase pump that resides on the luminal surface of the parietal cell membrane. This topic review will provide an overview of the mechanism of action, pharmacokinetics, administration, and adverse effects of PPIs.