In this review, general characteristics of Nrf2 and PPARγ pathways in the context of oxidative protection will be summarized first. Then, a number of successful applications of combined or separate use of Nrf2 and PPARγ activators for amelioration of pathological and drug-induced oxidative injuries will be discussed later. 2.

Microarray expression profiling revealed that lung peroxisome proliferator activated receptor γ (PPARγ) induction is suppressed in hyperoxia-susceptible Nrf2 -deficient (Nrf2−/−) mice compared with wild-type (Nrf2+/+) mice. PPARγ has pleiotropic beneficial effects including antiinflammation in multiple tissues.

The crosstalk between PPARs and Nrf2 (NF-E2-related factor 2), has been evidenced to play an important role not only in modulating inflammatory process, but also oxidative stress.

Sep 29, 2020 · It is known that nuclear factor-erythroid 2-related factor/antioxidant responsive element (NRF2/ARE) and peroxisome proliferator-activated receptor gamma/PPAR-γ response element (PPAR-γ/PPRE) pathways control inflammation and overcome mitochondrial impairment.

Aug 15, 2012 · In lung adenocarcinoma epithelial A549 cells, silencing of KEAP1 augmented the expression of peroxisome proliferator-activated receptor γ (PPARγ) and genes associated with cell differentiation, including E-cadherin and gelsolin.

Jan 10, 2023 · In breast cancer (BC), emerging evidence indicates that increased Nrf2 activity enhances cell metastatic potential. An interconnection between peroxisome proliferator-activated receptors (PPARs) and Nrf2 pathways in cancer has been shown.

Apr 9, 2024 · Serum and placental tissue are collected from healthy subjects and PE patients. The PPARγ and Nrf2 decreases in the PE. Rosiglitazone intervention reverses hypoxia-induced trophoblast ferroptosis...

Nrf2 (nuclear factor erythroid 2-related factor 2, NFE2L2) transcription factor functions as a target nuclear receptor against oxidative stress and is a key factor in redox regulation in hypertension and cardiovascular disease. Nrf2 mediates transcriptional regulation of a variety of target genes.

This timely paper highlights the importance of Nrf2 as a master proximal regulator of antioxidant responses, and identifies PPARγ as a key effector molecule in Nrf2-mediated effects.

Aug 27, 2017 · In this report, Hsu et al. identified monascin as novel natural Nrf2 and PPARγ agonists by using Nrf2 and PPARγ promoter reporter assays in HepG2 cells. Activation of Nrf2 pathway by monascin also resulted in downregulation of hyperinsulinemia in an oral glucose tolerance test [ 87 ].