Since AMPK is an important regulator in energy metabolism, it may be a key downstream target of PPARs, as indicated by the convergence of PPAR agonists' actions on AMPK. Overall, the effects of PPAR agonists on AMPK-mediated metabolic functions may contribute to the recovery of insulin sensitivity or treatment of metabolic syndrome ( Table 1 ).

amp-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-α (PPAR-α) are critical regulators of fatty acid oxidation. AMPK phosphorylates and inhibits acetyl CoA carboxylase and activates malonyl-CoA decarboxylase.

AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-α (PPAR-α) are critical regulators of short-term and long-term fatty acid oxidation, respectively. We examined whether the activities of these molecules were coordinately regulated.

Aug 8, 2010 · PPARα activators including fenofibrate and WY14643 activate AMPK signaling pathway in a receptor-independent manner (Figure 4). However, the mechanisms of these ligands on AMPK activation differ from each other.

Comprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARalpha, PPARbeta/delta, and PPARgamma, regulate cell growth, morphogenesis, differentiation, and homeostasis.

AMPK activation increases fatty acid oxidation in skeletal muscle by decreasing malonyl CoA concentrations. Activation of AMPK by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) increases mRNA expression of PPARα target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle.

Activation of adenosine monophosphate-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy through peroxisome proliferators-activated receptor-α (PPARα) signaling pathway, but the detailed mechanism remains unclear.

Jun 14, 2021 · Peroxisome proliferator-activated receptors (PPARs) are fatty acid sensors that regulate whole-body metabolism. Activation of PPARγ (for example, by glitazones) improves the management of...

Mar 20, 2016 · The combined activation of the cellular energy sensor AMP ‐activated protein kinase (AMPK) and the nuclear transcription factor peroxisome proliferator‐activated receptor delta (PPAR δ) has been demonstrated to improve endurance and muscle function by mimicking the effects of exercise training.

Aug 8, 2008 · A more critical role of AMPK in the super-endurance phenotype is revealed in our unexpected finding that, the orally active AMPK agonist AICAR is sufficient as a single agent to improve running endurance by nearly 45% in non-exercised mice.